Protocol Number: 92-M-0262

Title:

Neuropsychiatric Evaluation of Normal Subjects and Psychiatric and Neurologic Contrast Groups

Number:

92-M-0262

Summary:

The purpose of this study is to evaluate the cognitive processes of participants with schizophrenia, participants with nervous system and mental disorders, and healthy volunteers.

Participants in this study will undergo cognitive tests of attention, memory, attention. Participants with attention deficit hyperactivity disorder (ADHD), traumatic brain injury (TBI), bipolar disorder, and Alzheimer's disease (AD) will be compared with participants with schizophrenia. A group of healthy adults and children will undergo cognitive tests to further delineate the degree of impairment in schizophrenia and neurological disorder participants.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA

English-speaking adults between ages 21 to 65, in good health and free from significant substance abuse.

Children between ages 4 to 20 must not have a history of special education, using psychotropic medication in long-term counseling or with a history of seizures, head injury or CNS infections.

Normal controls will be recruited and screened for exclusionary morbidity by interview (e.g., no history of contact with mental health professionals, no history of diagnosable alcohol and/or substance abuse).

Normal controls will be recruited from building employees, local universities, from NIMH rosters, and the general public.

EXCLUSION CRITERIA

Excluded are adults with histories of dementing illness, movement disorder, affective disorders, developmental and/or acquired brain injury. Diagnoses will be made by review of medical records, interview, examination, and in the case of psychiatric diagnoses, a structured interview by SCID.

Advertisement will make clear that the subjects will be asked questions about family psychiatric history and their own history or psychiatric disorder, substance abuse, and neurological disease. Only if the subject answers these negatively will he or she participate in this study.

Special Instructions: Currently Not Provided

Keywords:

Cognition

Neuropsychology

Neuropsychological Tests

Neurological Exam

Psychiatric

Attention

Schizophrenic

Schizoaffective

Working Memory

Memory

Recruitment Keywords:

None

Conditions:

Brain Injury

Dementia

Healthy

Mental Disorder

Schizophrenia

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Terry E. Goldberg, Ph.D.
National Institutes of Health
Building 10
Room 4S231C
10 Center Drive, MSC 1379
Bethesda, Maryland 20892-1379
Phone: (301) 402-7810
Fax: (301) 480-7795

Electronic Address: goldbert@intra.nimh.nih.gov

Citations:

Further evidence for dementia of the prefrontal type in schizophrenia

Schizophrenia and brain dysfunction: an integration of recent neurodiagnostic findings

Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia: I regional cerebral blood flow (rCBF) evidence

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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/20/2004