Protocol Number: 93-M-0170

Title:

Regional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory

Number:

93-M-0170

Summary:

The purpose of this study is to use brain imaging technology to measure changes in blood flow to areas in the brain as individuals perform intellectual tasks.

This study will use functional magnetic resonance imaging (fMRI) to examine blood flow to areas of the brain as participants engage in tasks associated with visual perception, visual recognition, and memory.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

Healthy controls will be recruited from the NIH campus, through the normal volunteer program, and from the surrounding community.

INCLUSION CRITERIA:

Normal right handed adults, with at least a high school education, aged 20 to 65 years, will be recruited to participate in the study.

EXCLUSION CRITERIA:

Subjects will be excluded if they have evidence of, or a history of, learning disability, psychiatric condition, head trauma, seizures or other neurological condition, alcoholism or substance abuse, hypertension, or cardiovascular disease.

We will also exclude subjects with vision and/or hearing problems severe enough to interfere with testing.

Females with a positive pregnancy test will be excluded from neuroimaging studies.

All subjects will be questioned prior to MRI scanning for possible occupational exposure to metal slivers or shavings, which may have become accidentally lodged in the tissues of the head or neck. Those whose history is suggestive of such a problem will be excluded. Subjects with surgical clips or shrapnel in or near the brain or blood vessels, subjects with cochlear implants, subjects with any metallic body in the eye or CNS, and subjects with any form of implant wire or metal device which may concentrate radiofrequency fields will be excluded because of possible risks during MRI scanning.

Special Instructions: Currently Not Provided

Keywords:

Cognition

Vision

Cortex

Visual Processing

Magnetic Resonance Imaging

Recruitment Keywords:

None

Conditions:

Cognition Disorder

Healthy

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:

Corticocortical connections of anatomically and physiologically defined subdivisions within the inferior parietal lobule

Organization of visual inputs to the inferior temporal and posterior parietal cortex in macaques

Organization of afferent input to subdivisions of area 8 in rhesus monkey

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/20/2004