NIH Clinical Research Studies

Protocol Number: 93-N-0151

Active Accrual, Protocols Recruiting New Patients

Title:
Evaluation and Treatment of Patients with Spinal Vascular Abnormalities
Number:
93-N-0151
Summary:
Arteriovenous malformations (AVM) are abnormally formed blood vessels that can be located throughout the brain and spinal cord. Patients with abnormalities of the blood vessels located in and around the spinal cord can develop many neurological problems. Some problems include, weakness, pain, difficulty walking, paralysis, and even death.

The treatment for these AVMs depends on their location, the type of malformation, the area of the spine involved, and the condition of the patient at the time of treatment. The treatment is aimed at stopping the neurologic problems from worsening and possibly correcting the existing problems. There are two commonly used treatments for AVMs, surgery and embolization (blocking off of blood flow to the AVM).

However, researchers have limited experience treating these conditions because they are rare. In addition, it has been difficult to classify different kinds of AVMs and to develop new treatments for them.

This study is designed to increase researchers understanding of AVMs by admitting and following patients diagnosed with the condition. By increasing the amount of patients studied diagnosed with spinal blood vessel abnormalities, researchers can begin to develop new management plans for patients with AVMs.

Sponsoring Institute:
National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): None

Eligibility Criteria:
Patients suspected to have spinal arteriovenous malformations (AVM's) will be admitted to the Clinical Center for futher investigation and treatment. The presence of a spinal AVM will have been suggested by the studies performed at the referral center. These will include myelography, MRI scanning, and, in some instances, selective spinal arteriography.
Special Instructions: Currently Not Provided
Keywords:
Spinal Arteriovenous Malformations
Spinal Dural Arteriovenous Fistulas
Surgery
Embolization
Spinal Arteriography
Recruitment Keywords:
None
Conditions:
Arteriovenous Fistula
Arteriovenous Malformation
Spinal Cord Disease
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Microvascular anatomy of dural arteriovenous abnormalities of the spine: a microangiographic study

Surgical interruption of intradural draining vein as curative treatment of spinal dural arteriovenous fistulas

Spinal arteriovenous malformations

Active Accrual, Protocols Recruiting New Patients

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