INCLUSION CRITERIA:
Patients must have a tissue-diagnosis of grade 1, 2 and/or 3 A/B LYG (or a diagnosis consistent with LYG) confirmed by the Laboratory of Pathology, NCI.
Patients with any stage of disease will be eligible.
Previously untreated and treated patients are eligible.
Patients age 12 or older will be eligible.
Informed consent must be obtained.
EXCLUSION CRITERIA:
Female patients who are pregnant or lactating are not eligible to recieve treatment but can be followed for natural history.
Patients with a history of coronary artery disease with angina pectoris, or a history of congestive heart failure will not be eligible to receive DA-EPOCH-R chemotherapy.
Patients with significant renal (Cr. greater than 1.5 mg/dl or creatinine clearance less than 40 cc/min) or hepatic (bilirubin greater than 2.5 u) dysfunction not due to tumor involvement will not be eligible to receive DA-EPOCH-R chemotherapy.
Patients, who in the opinion of the principal investigator, are poor psychiatric or medical risk are not eligible.
Patients who received greater than 450 mg/m(2) doxorubicin and have a cardiac ejection fraction on MUGA scan less than or equal to 40% on protocol entry are not eligible to receive DA-EPOCH-R.