Protocol Number: 95-HG-0158

Title:

Genetic Analysis of Hereditary Prostate Cancer

Number:

95-HG-0158

Summary:

The purposes of this study are to determine if prostate cancer is inherited in some families, to find the gene or genes responsible for hereditary prostate cancer, and to understand how the gene(s) cause prostate cancer.

Participants will be enrolled through institutions collaborating in the National Human Genome Research Institute/Johns Hopkins University multi-center study to identify the gene for hereditary prostate cancer. Eligibility for this study is based on the following family characteristics:

1. a cluster of three or more first degree relatives, such as a father and two sons or three brothers, or

2. prostate cancer in each of three generations in either the patient's mother's or father's family

3. two first or second degree relatives affected at an early age (55 years or younger).

Participants are not seen at the National Institutes of Health and have no contact with NHGRI researchers. The collaborating institutions - Johns Hopkins University, Baltimore, Maryland; University of Maryland; Marshfield Medical Research Foundation, Marshfield, Wisconsin; Mayo Clinic, Rochester, Minnesota; Howard University, Washington, D.C.; Seattle Prostate Consortium, Seattle, Washington; Tampere University, Tampere, Finland; University of Michigan, Ann Arbor, Michigan; University of Lund, Lund Sweden are responsible for the clinical management of participants.

As part of this study, blood samples from patients and family members in the NHGRI/JHU study are collected and sent to NHGRI for laboratory genetic testing and statistics analyses. For this procedure, participants are required to answer questions by telephone about their personal and family medical history, provide a blood sample for genetic testing, and complete a written questionnaire. Some family members may also be asked to provide a blood sample and answer personal and family health questions by phone.

In addition, blood samples may be requested for chromosome analysis in families with one or more members affected by conditions such as developmental delay, mental retardation, a birth defect or multiple miscarriages. Chromosomes are hereditary units made up of genes. If a variation, or rearrangement, of the normal chromosome configuration is found, it might shorten the search for the hereditary prostate cancer gene.

Sponsoring Institute:

National Human Genome Research Institute (NHGRI)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

Enrollment in this study will be limited to affected individuals from families that meet the following criteria for Hereditary Prostate Cancer:

1. A cluster of 3 or more first degree relatives, such as a father and 2 sons or 3 brothers, or;

2. The occurrence of prostate cancer in each of 3 generations in either the proband's paternal or maternal lineages, or;

3. Two first or second-degree relatives affected at an early age (age 55 years or younger).

Special Instructions:

Subject involvement in this study includes one or more telephone conversations with an investigator; provision of a personal and family medical history; provision of a blood sample; agreement for personal medical record review and completion of a questionnaire.

Keywords:

Genotyping

Linkage Analysis

Adenocarcinoma

Micro Satellite

Hereditary

Recruitment Keywords:

Prostate Cancer (hereditary)

Conditions:

Hereditary Neoplastic Syndrome

Prostatic Neoplasm

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:

Localization of metastatic suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11

The molecular genetics of cancer

Hereditary cancer, oncogenes, and anti-oncogenes

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
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Warren Grant Magnuson Clinical Center (CC)
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Bethesda, Maryland 20892. Last update: 10/16/2004