NIH Clinical Research Studies

Protocol Number: 96-M-0124

Active Accrual, Protocols Recruiting New Patients

Title:
Genetics of Obsessive-Compulsive Disorder: A Collaborative Study
Number:
96-M-0124
Summary:
The purpose of this study is to identify genes that affect susceptibility to obsessive-compulsive disorder (OCD). By identifying genes that increase or decrease the risk of OCD, researchers can better understand how the condition develops and ultimately improve treatment for people with OCD.

OCD is a severe, familial condition that affects approximately 2% of the population. The way OCD is inherited is not clearly understood, but researchers believe it is complex and involves multiple genes. This study will detect and localize genes that increase or decrease susceptibility to OCD. The data collected from this study will be combined with data from other research studies to determine gene linkage and association.

Sponsoring Institute:
National Institute of Mental Health (NIMH)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): Children

Eligibility Criteria:
INCLUSION CRITERIA

Must have a diagnosis of obsessive-compulsive disorder, or be a family member (usually a parent or sibling) of someone with obsessive-compulsive disorder.

Certain disorders are considered part of OCD "spectrum" disorders and often include family members with OCD. These include Tourette's Syndrome, other individuals with tics, and Trichotillomania (severe hair pulling), and other forms of repetitive behaviors.

Persons with primary behavioral difficulties who do no fit with the current definitions of "OCD and OCD spectrum disorders" may not be eligible. These include compulsive shopping, gambling, or compulsive sexual behaviors.

Special Instructions:
You may call toll free at 866-644-4363 or collect at 31-496-8977.
Keywords:
Genetic
Psychiatric Disorder
Affected Sib Pairs
Obsessions
Compulsions
Family Study
OCD Spectrum Disorders
Trichotillomania
Tourette's Syndrome
Recruitment Keywords:
None
Conditions:
Obsessive Compulsive Disorder
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Diane M. Kazuba
National Institutes of Health
Building 10
Room 3D41
10 Center Drive
Bethesda, Maryland 20892
Phone: (301) 496-8977
Fax: (301) 402-0188
Electronic Address: kazubad@intra.nimh.nih.gov

Citations:
Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, Lesch KP, Hamer D, Murphy DL. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet. 2000 Apr 3;96(2):202-16. PMID: 10893498

Enoch MA, Greenberg BD, Murphy DL, Goldman D. Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder. Biol Psychiatry. 2001 Feb 15;49(4):385-8. PMID: 11239910

Murphy DL, Li Q, Engel S, Wichems C, Andrews A, Lesch KP, Uhl G. Genetic perspectives on the serotonin transporter. Brain Res Bull. 2001 Nov 15;56(5):487-94. Review. PMID: 11750794

Bengel D, Greenberg BD, Cora-Locatelli G, Altemus M, Heils A, Li Q, Murphy DL. Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder. Mol Psychiatry. 1999 Sep;4(5):463-6. PMID: 10523819

Enoch MA, Kaye WH, Rotondo A, Greenberg BD, Murphy DL, Goldman D. 5-HT2A promoter polymorphism -1438G/A, anorexia nervosa, and obsessive-compulsive disorder. Lancet. 1998 Jun 13;351(9118):1785-6. No abstract available. PMID: 9635956

Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, Ott J, Gogos JA. Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4572-5. PMID: 9114031

Altemus M, Murphy DL, Greenberg B, Lesch KP. Intact coding region of the serotonin transporter gene in obsessive-compulsive disorder. Am J Med Genet. 1996 Jul 26;67(4):409-11. PMID: 8837711

Active Accrual, Protocols Recruiting New Patients

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