Protocol Number: 96-N-0088

Title:

Characteristics of Idiopathic Familial Speech Disorders

Number:

96-N-0088

Summary:

According to studies, speech disorders with unknown causes (idiopathic) affect approximately 5% of the population at some point in their life. Some of these disorders like, stuttering and cluttering, are known for being detected early, during speech development.

Stuttering is characterized by sound and syllable repetitions and consonant/vowel prolongations. When stuttering is moderate to severe, it can interfere with a person's job and social activities.

Speech articulation disorders are characterized by omissions, or substitutions of speech sounds. The speech of a person who clutters is often difficult to understand. People are often unaware of the errors they make when speaking causing treatment of the condition to be very difficult.

The purpose of this research is to study an extended family whose members exhibit a pure form of speech articulation disorders

In addition, the study will use data and information gathered from the study and use it to develop guidelines (criteria) for defining and differentiating patients with speech disorders.

Sponsoring Institute:

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

Developmental stuttering with onset prior to puberty with or without subsequent recovery.

Developmental phonological disorders includes speech sound omissions or errors during conversational speech with poor error awareness with or without subsequent recovery.

EXCLUSION CRITERIA:

Individuals who developed stuttering following brain injury.

Special Instructions: Currently Not Provided

Keywords:

Stuttering

Linkage

Pedigree

Speech Articulation

Phonological Processing Disorders

Recruitment Keywords:

Speech Disorder

Conditions:

Developmental Articulation Disorder

Speech Disorder

Stuttering

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:

The genetic basis of complex human behaviors

Some environmental factors and hypotheses for stuttering in families with several stutterers

Familial aggregation of phonological disorders: results from a 28-year follow-up

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/23/2004