INCLUSION CRITERIA:
All patients must have a histologically confirmed diagnosis of Hodgkin's disease, non-Hodgkin's lymphoma or lymphoid leukemia.
At least 10% of each patient's malignant cells from peripheral blood, lymph node, skin, or other extranodal sites must react with anti-Tac , as determined by immunofluorescent or immunoperoxidase staining.
Diagnoses and Stage of Disease:
1) Non-Hodgkin's Lymphoma (NHL): Patients with all histopathologic subtypes of Tac-expressing NHL are eligible. Patients with indolent NHL Stages II through IV are eligible if they have failed at least one standard therapy and have disease requiring treatment. Patients with aggressive NHL are eligible if they have relapse after standard chemotherapy and either are not eligible for or have refused salvage chemotherapy or bone marrow transplantation.
2) Hodgkin's disease: Patients who are considered to have a low potential for cure with conventional chemotherapy or radiation therapy are eligible. Specifically, patients with stages II-IV Hodgkin's disease are eligible if they have relapsed or failed to attain a complete remission after first-line chemotherapy and either are not eligible for or have refused salvage chemotherapy or bone marrow transplantation.
3) Cutaneous T-cell Lymphoma (CTCL): Patients with all stages of Tac-expressing CTCL are eligible with the exception of Stage Ia. Patients with Stages Ib through III are eligible if they have failed at least one standard therapy. Patients with stage IV are eligible regardless of whether they have had previous therapy.
4) Peripheral T-cell Lymphoma (PTCL): Patients with stages I-IV PTCL are eligible if they have relapsed after first-line chemotherapy and either are not eligible for or have refused salvage chemotherapy or bone marrow transplantation.
Other: Patients with lymphoid leukemias or lymphomas not easily classified in the above categories will be eligible providing they have failed standard therapy and are not eligible for or have refused bone marrow transplantation.
Patients must have a Karnofsky performance status of at least 50.
Patients must have a creatinine of less than 2.0 mg/dl. If they patient has an abnormally elevated creatinine a creatinine clearance must be greater than 50 ml/min.
Patients must have SGOT and SGPT less than 2.5 times the upper limit of normal, bilirubin less than 2.0 unless this is felt to be due to the malignancy.
Patients must not have clinical cardiac failure. Patients with symptomatic pulmonary dysfunction are eligible only if it is due to the underlying malignancy.
The patients must have a granulocyte count of at least 1,500/mm(3) and a platelet count of greater than 100,000/mm(3).
Patients must be able to understand and sign informed consent.
Breast-feeding females are not eligible for the study.
Omission of cytotoxic chemotherapy or other systemic therapy of the malignancy for 3 weeks prior to entry into trial. However, patients receiving corticosteroids will not be excluded. Patients receiving corticosteroids must be on a stable dose for at least three weeks before receiving 90Y-HAT on this study.
Patients must have a life expectancy of greater than 1 month.
Patients must be at least 18 years old.
EXCLUSION CRITERIA:
Female patients of child bearing potential will be tested for pregnancy; pregnant patients will be excluded from the study.
Patients who are HIV antibody positive.
Patients with a history of prior bone marrow transplant.
Patients with symptomatic disease that is due to malignant involvement of the central nervous system.
Patients with active second primary cancer.
Patients receiving chronic anticoagulant therapy will be excluded from the study.
Patients requiring urgent chemotherapy or radiation therapy for management of their malignancy will be excluded.
Warren Grant Magnuson Clinical Center (CC)