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Protocol Number:
97-H-0130
- Title:
Collection of Blood and Bone Marrow from Normal Volunteers and Patients for Research Purposes
- Number:
97-H-0130
- Summary:
This study is designed to provide bone marrow and/or blood cells for other research studies. Patients participating in this study will be asked to provide small amounts of medical information and undergo a limited physical examination designed to detect the presence of any obvious blood disease. A blood and bone marrow sample will be obtained to verify that the patient has normal blood cell production.
Researchers plan to obtain bone marrow samples to be used in laboratory studies directed toward understanding the formation of blood cells. Bone marrow samples will be taken from the hip bone of patients and normal volunteers.
These samples are valuable to many research studies within the Hematology Branch of the National Heart, Lung, and Blood Institute, including studies of normal and abnormal production of blood cells, the viral causes of blood diseases, and the role of the immune system in bone marrow failure and related conditions.
- Sponsoring Institute:
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National Heart, Lung and Blood Institute (NHLBI)
- Recruitment Detail
- Type:
Active Accrual Of New Subjects
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
None
- Eligibility Criteria:
INCLUSION CRITERIA:
Normal volunteers age greater than or equal to 18 years.
Subjects with hematologic disease age greater than or equal to 2 (for subjects less than 18, blood and bone marrow specimens will be obtained concurrently with clinically indicated sampling).
EXCLUSION CRITERIA:
History of a significant bleeding disorder.
Abnormal host-defense mechanisms.
- Special Instructions:
This protocol includes:
1. Bone Marrow Aspiration: Aspirates are obtained from the posterior iliac spine.
2. Bone Marrow Biopsy: The bone marrow biopsy core is obtained with a Jamshidi needle using standard clinical techniques.
3. Peripheral Blood: From 20-100 ml of blood is obtained by venipuncture from a peripheral vein.
- Keywords:
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Bone Marrow
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Hematopoiesis
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DNA
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RNA
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Viruses
- Recruitment Keywords:
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Normal Volunteer
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Aplastic Anemia
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Myelodysplasia
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Fanconi's Anemia
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Single Lineage Cytopenia
- Conditions:
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Aplastic Anemia
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Fanconi's Anemia
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Healthy
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Hematologic Disease
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Myelodysplastic Syndrome
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Contacts:
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Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citations:
Not Provided
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Warren Grant Magnuson Clinical Center (CC) National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/23/2004
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