NIH Clinical Research Studies

Protocol Number: 97-H-0130

Active Accrual, Protocols Recruiting New Patients

Title:
Collection of Blood and Bone Marrow from Normal Volunteers and Patients for Research Purposes
Number:
97-H-0130
Summary:
This study is designed to provide bone marrow and/or blood cells for other research studies. Patients participating in this study will be asked to provide small amounts of medical information and undergo a limited physical examination designed to detect the presence of any obvious blood disease. A blood and bone marrow sample will be obtained to verify that the patient has normal blood cell production.

Researchers plan to obtain bone marrow samples to be used in laboratory studies directed toward understanding the formation of blood cells. Bone marrow samples will be taken from the hip bone of patients and normal volunteers.

These samples are valuable to many research studies within the Hematology Branch of the National Heart, Lung, and Blood Institute, including studies of normal and abnormal production of blood cells, the viral causes of blood diseases, and the role of the immune system in bone marrow failure and related conditions.

Sponsoring Institute:
National Heart, Lung and Blood Institute (NHLBI)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): None

Eligibility Criteria:
INCLUSION CRITERIA:

Normal volunteers age greater than or equal to 18 years.

Subjects with hematologic disease age greater than or equal to 2 (for subjects less than 18, blood and bone marrow specimens will be obtained concurrently with clinically indicated sampling).

EXCLUSION CRITERIA:

History of a significant bleeding disorder.

Abnormal host-defense mechanisms.

Special Instructions:
This protocol includes:

1. Bone Marrow Aspiration: Aspirates are obtained from the posterior iliac spine.

2. Bone Marrow Biopsy: The bone marrow biopsy core is obtained with a Jamshidi needle using standard clinical techniques.

3. Peripheral Blood: From 20-100 ml of blood is obtained by venipuncture from a peripheral vein.

Keywords:
Bone Marrow
Hematopoiesis
DNA
RNA
Viruses
Recruitment Keywords:
Normal Volunteer
Aplastic Anemia
Myelodysplasia
Fanconi's Anemia
Single Lineage Cytopenia
Conditions:
Aplastic Anemia
Fanconi's Anemia
Healthy
Hematologic Disease
Myelodysplastic Syndrome
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations: Not Provided

Active Accrual, Protocols Recruiting New Patients

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