Protocol Number: 98-C-0137

Title:

Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Cryptococcus neoformans Infection in Patients not Infected with HIV and Complications Associated with Cryptococcus neoformans Infection

Number:

98-C-0137

Summary:

Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or clinical course of infection with Cryptococcus neoformans. To test this hypothesis, we propose to analyze the allelic frequencies of 15 different genes (mannose binding lectin, Fc-gamma receptor IIa and IIb, Fc-gamma receptors IIIa and IIIb, myeloperoxidase, tumor necrosis factor-alpha and -beta, interleukin 1A and 1B, interleukin-1 receptor antagonist, interleukin-10, NRAMP-1, chitotriosidase, and chemokine receptor 5) and their intragenic polymorphic forms and to compare this data to the incidence and severity of C neoformans infection. With this study we hope to identify a group of molecules of innate immunity which influence the risk and severity of invasive C neoformans infection.

Sponsoring Institute:

National Cancer Institute (NCI)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: Yes

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

Patients diagnosed with Cryptococcus neoformans infection will be identified from a data base overseen by Dr. Peter Pappas.

Only patients diagnosed and treated in the United States and Canada will be included in this analysis.

Only patients who are not coinfected with HIV will be included in the study.

Patient samples will be collected and clinical data will be evaluated only after signed informed consent has been obtained.

Special Instructions: Currently Not Provided

Keywords:

Risk Factor

Genetic

Variant Alleles

Cancer

Transplantation

Recruitment Keywords:

None

Conditions:

Cryptococcosis

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

CSSC
Clinical Studies Support Center/NCI
164 Rollins Avenue
2nd FLoor
Rockville, MD 20852
Phone: (888) 624-1937
Fax: (301) 881-8239

Electronic Address: ncicssc@mail.nih.gov

Citations:

Variations in the NRAPM-1 gene and susceptibility to tuberculosis in West Africans

Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosis

Cloning od a cDNA encoding chitotrisdiase, a human chitinase produced by macrophages

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