INCLUSION CRITERIA:
All patients greater than 18 years old who are eligible for a treatment protocol evaluating a therapeutic modality which may have an effect on tumor associated vasculature.
Patients must have imageable disease by standard CT or MRI and at least one lesion measuring greater than 2 cm in diameter.
Patients must be willing to return to NIH for their imaging scans.
Patients must be able to sign informed consent.
EXCLUSION CRITERIA:
Patients must weigh greater than 136 kgs, which is the weight limit for the scanner tables.
Pregnancy or breast-feeding. A negative pregnancy test (urine or serum) is required prior to enrollment.
Renal insufficiency as determined by a serum creatinine greater than 2.0.
History of sensitivity to contrast agents which cannot be controlled with premedication
Patients with pacemakers, cerebral aneurysm clips, shrapnel injury or implantable electronic devices