NIH Clinical Research Studies

Protocol Number: 98-CC-0019

Active Accrual, Protocols Recruiting New Patients

Title:
Normal Volunteer Scanning on MR
Number:
98-CC-0019
Summary:
Magnetic resonance is an imaging technique that uses magnetic fields and radio waves to create images of the body. The technology used in magnetic resonance imaging continues to improve. Advancements in magnetic resonance imaging (MRI) requires researchers to study new techniques in normal volunteers in order to understand how to use them in patients with diseases.

In this study researchers plan to do a variety of diagnostic tests including magnetic resonance imaging on normal volunteers. The studies may involve injections of contrast media, substances injected into the blood of participant that improves the image created by the MRI scanner. The study is not expected to benefit the participants. However, information gathered from the study may be used to improve diagnostic techniques and develop new research studies.

Sponsoring Institute:
Warren G. Magnuson Clinical Center (CC)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): None

Eligibility Criteria:
INCLUSION CRITERIA:

Any normal volunteer above the age of 18 who is capable of giving informed consent.

EXCLUSION CRITERIA:

A subject will be excluded if he/she has a contraindication to MR scanning such as surgery that involves metal clips or wires which might be expected to concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field. Examples include: aneurysm clip, implanted neural stimulator, implanted cardiac pacemaker or autodefibrillator, cochlear implant, ocular foreign body (e.g., metal shavings), any implanted device (pumps, infusion devices, etc), shrapnel injuries.

For studies involving the use or Optison (microbubble contrast agent), subjects will be excluded if they have severe liver or lung disease, congenital heart defects, history of pulmonary emboli, or known or suspected hyper-sensitivity (allergic reaction) to blood, blood products or albumin.

Subjects will be excluded if it is deemed that they have a condition which would preclude their use for technical development (e.g., paralyzed hemidiaphragm, morbid obesity, claustrophobia, etc.) or present unnecessary risks (e.g. pregnancy, surgery of uncertain type, symptoms of pheochromocytoma or insulinoma, etc.)

Lactating women and subjects with hemoglobinopathies, asthma, or renal or hepatic disease will be excluded from studies involving the administration of contrast agents.

Special Instructions: Currently Not Provided
Keywords:
Magnetic Resonance Imaging
Gadolinium
Magnetic Resonance Angiography
Recruitment Keywords:
Normal Volunteer
Conditions:
Healthy
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Renal Cancer: pre-operative evaluation with dual phase three dimensional MR angiography

Tolerance data of Gd-DTPA: a review

Measurement of relative cerebral blood volume changes with visual stimulation by 'double-dose' gadopentate-dimeglumine-enhanced dynamic magnetic resonance imaging

Active Accrual, Protocols Recruiting New Patients

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National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/15/2004

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