Protocol Number: 98-N-0047

Title:

Immuno-Virological Evaluation of Human T Cell Leukemia Virus Type-1 Associated Myelopathy (HAM/TSP)

Number:

98-N-0047

Summary:

The purpose of this study is to obtain blood samples from three groups of subjects;

1. Patients infected with human T cell leukemia virus type-1 (HTLV-1) and clinical symptoms of HTLV-1 associated myelopathy (HAM) / tropical spastic paraparesis (TSP)

2. Family members of patients infected with human T cell leukemia virus type-1 (HTLV-1) and clinical symptoms of HTLV-1 associated myelopathy (HAM) / tropical spastic paraparesis (TSP)

3. Patients who have inconclusive blood test results on the presence of HTLV-1

The specimens will be used evaluate immune system function and to measure levels of the virus.

Sponsoring Institute:

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: Yes

Population Exclusion(s): Children

Eligibility Criteria:

INCLUSION CRITERIA:

- Positive HTLV-I EIA or Western blot positive for HTLV-I bands.

- Willingness to participate in the protocol evaluations and procedures.

EXCLUSION CRITERIA:

- Unwillingness or inability participate in the protocol evaluations and procedures.

- The presence of any medical, social, or psychiatric conditions that in the opinion of the investigator may affect the safety of the patients or compliance with the protocol.

- Children under the age of 18 are excluded.

Special Instructions: Currently Not Provided

Keywords:

Immune Response

Sero-Indeterminant

Transmission

Tropical Spastic Paraparesis

Viral Load

Recruitment Keywords:

HTLV-I

HAM/TSP

Conditions:

HTLV-I Infection

Tropical Spastic Paraparesis

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:

Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A, de The G. Related Articles, Links Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet. 1985 Aug 24; 2(8452): 407-10.

PMID: 2863442

Osame M, Matsumoto M, Usuku K, Izumo S, Ijichi N, Amitani H, Tara M, Igata A. Related Articles, Links Chronic progressive myelopathy associated with elevated antibodies to human T-lymphotropic virus type I and adult T-cell leukemialike cells.

Ann Neurol. 1987 Feb; 21(2): 117-22. PMID: 2881513

Iwasaki Y. Related Articles, Links Pathology of chronic myelopathy associated with HTLV-I infection (HAM/TSP).

J Neurol Sci. 1990 Apr; 96(1): 103-23. PMID: 2351985

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