NIH Clinical Research Studies

Protocol Number: 99-H-0037

Active Accrual, Protocols Recruiting New Patients

Title:
Apheresis of Family Members of Patients Undergoing Allogeneic Bone Marrow Transplantation. A Pre-Clinical Study of Selective Depletion of Donor Lymphocytes to Prevent Acute Graft-Versus-Host Disease
Number:
99-H-0037
Summary:
Blood contains different kinds of cells, white blood cells, red blood cells, and platelets. In order to treat certain diseases, specific cell types can be removed from blood and transplanted into patients. The process of removing white blood cells for the treatment of leukemia is called apheresis.

This study will make available blood cell collections from volunteers genetically matched to various degrees with recipients in order to test and, if necessary, refine the process of removing white blood cell T-lymphocytes.

Sponsoring Institute:
National Heart, Lung and Blood Institute (NHLBI)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): None

Eligibility Criteria:
INCLUSION CRITERIA:

Family members of patients admitted to NHLBI allogeneic BMT protocols for hematological malignancy or solid tumors .

Age 18-65 .

HLA type is determined in the course of searching for a donor, or parent of patient (obligate haplotype match) will be included.

HLA 3/6, 4/6, 5/6, 6/6 match with patient will be included.

Research apheresis must be available from patient.

Venous access suitable for apheresis using antecubital veins.

Signed consent .

EXCLUSION CRITERIA:

Less than 18 or greater than 65.

Pregnancy or lactation.

HLA type unknown.

III Volunteer not a parent of patient.

More than one haplotype mismatch with patient .

Venous access inadequate.

Research apheresis available from patient.

Special Instructions: Currently Not Provided
Keywords:
Volunteer
Leukocyte Donors
Family Members
Leukocyte Collection
No Reimbursement
Recruitment Keywords:
None
Conditions:
Graft vs Host Disease
Hematologic Neoplasm
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations: Not Provided

Active Accrual, Protocols Recruiting New Patients

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