Protocol Number: 99-M-0172

Title:

Integrating EEG/MEG and fMRI: Activity Correlation Between Frontal and Temporal Lobe Structures in Schizophrenic Patients, Their Siblings and Unrelated Normal Volunteers

Number:

99-M-0172

Summary:

This study will explore how the brain works during memory testing in an effort to understand why some patients with schizophrenia have memory difficulties.

Patients with schizophrenia and their unaffected family members are eligible for this study. Studying family members may help identify the genes related to the memory deficit in schizophrenia. Normal volunteers will also be studied.

Normal volunteers, patients with schizophrenia, and their family members interested in participating in this study will be screened with a complete medical examination and psychiatric assessment, and performance of simple tasks. Study participants will be shown numbers on a screen and asked to recall them after a brief period. This will be done during electroencephalographic (EEG) recording, in which electrodes attached to the scalp measure the brain's electrical activity. The same test will be repeated while the patient has magnetic resonance imaging of the brain. The combined MRI and EEG testing will permit better localization of the brain's electrical activity.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

Controls as well as patients and siblings will be recruited from the ongoing sibling study (95-M-0150). Subjects who are considered to be eligible will be considered eligible for this protocol, too. In addition, all patients should be medication-free (greater than three days) or on single-medication (unchanged medication for greater than 2 weeks).

EXCLUSION CRITERIA:

Anticipated psychomotor non-compliance, which may affect the measurement quality, will also be a reason for prior (temporary) exclusion from the study.

Special Instructions: Currently Not Provided

Keywords:

Functional Connectivity

Frontotemporal Interaction

Electrophysiology

Functional Magnetic Resonance Imaging

Healthy Subjects

Schizophrenia

Cortical Network Dysfunction

Neuroimaging

Brain Scan

MRI

Recruitment Keywords:

Schizophrenia

Conditions:

Healthy

Schizophrenia

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:

Relationship between electrical potentials of the hippocampus, amygdala and neocortex during instrumental conditioning reflexes

Combined dynamics of EEG and evoked potentials I studies of simultaneously recorded EEG-EPograms in the auditory pathway, reticular formation and hippocampus of the cat brain during the walking stage

P300-response: possible psychophysiological correlates in delta and theta frequency channels

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/16/2004