NIH Clinical Research Studies

Protocol Number: 00-AR-0222

Active Accrual, Protocols Recruiting New Patients

Title:
Studies of the Pathogenesis and Natural History of Arthritis and Related Conditions
Number:
00-AR-0222
Summary:
The purpose of this study is to learn more about the causes of rheumatoid arthritis, juvenile rheumatoid arthritis and related conditions and the course of these diseases. Patients in this study will not receive treatment, but may be offered participation in a treatment protocol if an appropriate study is available.

Children and adults of all ages with known or suspected arthritis are eligible for this study. Participants will undergo the following tests and procedures:

-Medical history and physical examination

- Measurements of weight and height

- Blood sample collections for clinical and research purposes

- X-rays of hand, feet or other affected joints, if x-rays have not been taken in the past 3 months and are medically indicated

- Magnetic resonance imaging (in some patients) to assess disease or study the usefulness of this diagnostic method for arthritis patients

- Quality of life questionnaires

- Stride analyzer test (children only) - computer system analysis of walking speed and pattern

- Hand functional test (children only) - detailed study of hand function

- Walk/run time (children only) - measurement of distance the child can walk or run in 9 minutes (heart rate and blood pressure are taken before and after the test)

-Synovial biopsy (in some patients) - removal of a sample of tissue from the synovium (lining of the joint) for evaluation under the microscope. The procedure is done under local anesthetic.

Sponsoring Institute:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): None

Eligibility Criteria:
INCLUSION CRITERIA:

No age limits.

History of inflammatory synovitis of at least one or more swollen joints.

Patient's ability and willingness to give informed consent or in the pediatric patients, the parent's willingness to give informed consent and the patient's willingness to assent to the protocol whenever possible.

EXCLUSION CRITERIA:

None if patients fulfill inclusion criteria.

Special Instructions: Currently Not Provided
Keywords:
Rheumatoid Arthritis
Inflammation
Synovitis
Genetics
Synovial Biopsy
Juvenile Arthritis
Arthritis
Recruitment Keywords:
Rheumatoid Arthritis
Juvenile Rheumatoid Arthritis
JRA
Conditions:
Arthritis
Synovitis
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Familial clustering of rheumatoid arthritis with other autoimmune diseases

Transin/stromelysin expression in rheumatoid synovium A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes

Juvenile rheumatoid arthritis as a complex genetic trait

Active Accrual, Protocols Recruiting New Patients

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