Protocol Number: 00-CH-0180

Title:

Endocrine Studies in Health and Disease

Number:

00-CH-0180

Summary:

This study will evaluate healthy normal volunteers and patients with a variety of endocrine disorders to 1) learn more about conditions that affect the endocrine glands (glands that secrete hormones) and 2) train physicians in endocrinology.

Patients with endocrine-related conditions and healthy volunteers of all ages may be eligible for this study.

All participants will have a physical examination medical and history. They may be required to provide blood, saliva or urine samples and undergo ultrasound (using sound waves) or magnetic resonance (using a magnetic field) imaging to visualize internal body structures.

Some healthy adult volunteers will have hormone-stimulating tests to assess endocrine function. These tests measure blood hormone levels before and after injection of a synthetic form of a hormone. A device called a heparin lock, through which the hormone is injected and the blood samples are collected, is placed in a vein in the arm or hand. Blood samples are drawn before the hormone is injected and at various intervals after the injection to measure levels of the hormone. These tests, which last from 1 to 3 hours, may include the following:

1. CRH stimulation test-corticotropin-releasing hormone is given to test pituitary and adrenal gland function

2. ACTH stimulation test-adrenocorticotrophic hormone is given to test adrenal gland function

3. LHRH stimulation test-luteinizing hormone-releasing hormone is given to test pituitary gland function

4. TRH stimulation test-thyroid-releasing hormone is given to test pituitary and thyroid gland function

5. GHRH stimulation test-growth hormone releasing hormone is given to measure growth hormone levels.

An oral glucose tolerance test, which is similar to the stimulation tests, may also be done to measure blood glucose (sugar) and insulin levels after drinking a sugary liquid.

Healthy volunteers and patients with a hereditary endocrine disorder and their family members may also be asked to provide a blood sample for genetic studies of inherited endocrine disorders. Patients with endocrine-related disorders may be offered medical or surgical treatment for their disorder.

Sponsoring Institute:

National Institute of Child Health and Human Development (NICHD)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA

Healthy subjects and patients with endocrine-related conditions of all ages are eligible for this protocol. The actual selection of patients most appropriate for clinical training needs will be made by protocol investigators.

Subjects with disabilities are not formally excluded from the study unless the disability would specifically prevent participation. If a subject with cognitive impairment wishes to participate, there must be available a family member or other qualified individual holding a durable power of attorney who is able to guide the impaired subject's participation and be an advocate for their interests. This participation is limited to the non-research, clinical training arm of the study.

Special Instructions:

This study is not currently recruiting normal volunteers at this time. However, normal volunteers will be recruited in the future for specific studies, each having specific inclusion criteria.

Keywords:

Evaluation

Endocrinology

Hormones

Metabolism

Teaching

Recruitment Keywords:

Endocrine Disorder

Conditions:

Endocrine Diseases

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations: Not Provided

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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Warren Grant Magnuson Clinical Center (CC)
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Bethesda, Maryland 20892. Last update: 10/21/2004