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Protocol Number:
00-D-0055
- Title:
Genetics of Pain
- Number:
00-D-0055
- Summary:
The purpose of this study is to learn more about the role of genetics in pain sensitivity. Pain perception varies widely among individuals, and information gained from this trial may lead to better methods of preventing and controlling pain. The study consists of two parts, described below. All enrollees will participate in part 1; patients needing oral surgery for removal of third molars may also participate in part 2.
Normal volunteers, oral surgery patients, and family members of both groups may be eligible for this study.
Part 1 -Sensitivity testing for hot and cold. Participants will rate their pain response to hot and cold stimuli on a scale from "no pain" to the "worst pain imaginable." Heat sensitivity is measured using a small probe placed on the skin for a few seconds. The hottest temperature tested may cause pain for a few seconds but will not produce a burn. Response to cold is measured by placing the hand in cold water for up to 3 minutes and occasionally flexing the fist. Participants will rate their pain level every 15 seconds. In addition to the testing, a blood sample will be drawn to examine for genes related to pain.
Part 2 - Oral surgery. Patients will have their third molar removed under a local anesthetic (lidocaine) injected in the mouth and a sedative (Versed) given through a vein in the arm. A small tissue biopsy will be taken from the tissue over one of the third molars. Patients will stay in the clinic for up to 7 hours after surgery while the anesthetic wears off and will rate any pain they may have according to the rating scale used in Part 1 of the study. Pain medication (ketorolac, or Toradol) will be given when needed, and patients will complete pain questionnaires for 3 hours after the drug is given to rate its effectiveness. Patients will receive additional pain relievers, if needed. A second biopsy on the side opposite the first will be taken under local anesthetic to measure changes in chemical signals produced in response to the surgery.
- Sponsoring Institute:
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National Institute of Dental And Craniofacial Research (NIDCR)
- Recruitment Detail
- Type:
Active Accrual Of New Subjects
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
None
- Eligibility Criteria:
INCLUSION CRITERIA:
Patients in need of oral surgery for removal of impacted third molar will be recruited from the local community and by physician or dental referrals.
EXCLUSION CRITERIA:
Use of prescription and nonprescription analgesics, antihistamines, and antidepressants. No history of psychiatric or neurological disorders or a positive score on the Beck Depression Inventory, those females who are pregnant or nursing.
- Special Instructions:
Healthy Volunteers currently are not being recruited for this protocol.
- Keywords:
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Genetic Markers
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Thermal Pain
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Hyperalgesia
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Oral Surgery
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Cold Pain
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Peripheral Nerve
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Allodynia
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Spinal Cord
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Personality Traits
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Pain Ratings
- Recruitment Keywords:
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None
- Conditions:
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Healthy
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Hyperalgesia
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Pain
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Contacts:
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Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citations:
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Measurements of human pressure-pain thresholds on fingers and toes
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Positron emission tomographic analysis of cerebral structures activated specifically by repetitive noxious heat stimuli
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Human pain responsivity in a tonic pain model: psychological determinants
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Warren Grant Magnuson Clinical Center (CC) National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/23/2004
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