Protocol Number: 00-DC-0073

Title:

Identification of Hereditary Auditory Temporal Processing Deficits

Number:

00-DC-0073

Summary:

Some children with certain language disorders may not properly process the sounds they hear, resulting in language impairments. The purpose of this study is to determine if deficits in auditory temporal processing-the way the brain analyzes the timing and patterns of sounds-are an inherited trait.

Families with auditory temporal processing deficits are sought in order to identify the genes responsible for auditory temporal processing deficits. Children and adults with a diagnosis or history of language impairment in the family and their family members-both affected and non-affected-are eligible for this two-part study. In Part 1, participants undergo a series of language tests and listening tests to measure various characteristics of how they perceive sound. In Part 2, they are interviewed about language disorders, learning disabilities, and other medical problems of family members. This information is used to construct a pedigree (family tree diagram) showing the pattern of inheritance of family traits. Study subjects whose pedigree indicates that language disorders may be hereditary in their family will provide either a small blood sample (1 to 2 tablespoons) or a tissue specimen obtained from a cheek swab (rubbing the inside of the cheek with a small brush or cotton swabs). The sample will be used to isolate DNA for genetic analysis.

Sponsoring Institute:

National Institute on Deafness and Other Communication Disorders (NIDCD)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

Affected and unaffected members of families segregating auditory temporal processing deficits.

Normal male and female volunteers age 12 to 50.

EXCLUSION CRITERIA:

Persons must not currently be taking psychotropic medication.

Persons must not require bilateral hearing aids.

Special Instructions:

Protocol is now recruiting new patients.

Keywords:

Temporal Processing

Language Impairment

Linkage Analysis

Inheritance

Language Delay

Healthy

Recruitment Keywords:

Auditory Temporal Processing Disorder

Language Impairment

Speech Impediment

Conditions:

Auditory Perceptual Disorder

Language Delay

Language Disorder

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:

Asperger's syndrome and semantic-pragmatic disorder: where are the boundaries?

Is specific language impairment a valid diagnostic category?

Prevalence of special language impairment in kindergarden children

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/23/2004