Protocol Number: 00-HG-0058

Title:

Genetic Analysis of Attention Deficit Hyperactivity Disorder (ADHD)

Number:

00-HG-0058

Summary:

Attention Deficit Hyperactivity Disorder (ADHD) is the most common behavioral disorder in childhood, affecting 3-5% of children between the ages of 7 and 17. Family studies suggest that there is a genetic component to ADHD. Scientists believe that it is a complex disorder in which two or more genes may be involved.

Potentially eligible families will be asked to give written consent to participate and will be asked to complete questionnaires for each member in the family. In addition, an interview will be administered to the parent of minors enrolled in the study to determine their eligibility for being in the study. This screening tool is computerized and will take approximately 45 minutes to administer per child.

Once screenings are completed, a blood collection kit will be sent to the family to take to their local medical care provider, have blood samples drawn and sent to NIH. There is no cost to the family to participate. We would like to enroll entire families, with both parents and all children.

Sponsoring Institute:

National Human Genome Research Institute (NHGRI)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

For both the U.S. and the Columbian Studies, we plan to obtain blood samples from subjects meeting the following criteria.

Children , ages 7-17, affected with ADHD with siblings who are either affected or unaffected, and their parents. (in the Columbian Study, we will also gather information and blood samples from extended families).

EXCLUSION CRITERIA:

Exclude the following (if the condition could cause false positive ADHD): Prematurity; neurological conditions; Cardiac surgery; Prenatal drug exposure; Hydrocephaly;Retardation (IQ of less than 80); Known genetic syndromes; Known CNS disorders; Known lead toxicity; Tourette Disorder; Obsessive-Compulsive Disorder; Major Depression on both proband and affected sibling; Pervasive Developmental Disorder; Age under 7 years old; Autism; Other Psychoses; Post Traumatic Stress Disorder; Language Disorder (if known); Severe Sensory Impairment (visual and hearing).

No bilineal families are to be included, i.e. families in which both father and mother are known to be affected with ADHD. In order to involve either parent, there must be affected siblings.

Include, but note: Oppositional Defiant Disorder; Conduct Disorder; Tic Disorder; Obsessive/Compulsive Symptoms; Anxiety/Phobias

Special Instructions: Currently Not Provided

Keywords:

Linkage

Gene Identification

Behavioral

Phenotype Psychiatric Disorder

Family Study

Recruitment Keywords:

None

Conditions:

Attention Deficit Disorder with Hyperactivity

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:

DSM-III disorders in preadolescent children Prevalence in a large sample from the general population

A prospective 4-year follow-up study of attention-deficit hyperactivity and related disorders

Genetic heterogeneity in attention-deficit hyperactivity disorder (ADHD): gender psychiatric comorbidity and maternal ADHD

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/16/2004