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Protocol Number:
00-I-0164
- Title:
Cognitive Function in Leukocyte Disorders
- Number:
00-I-0164
- Summary:
This study will try to determine what causes learning, behavioral and emotional problems in children with chronic granulomatous disease (GCD) and other phagocyte disorders. (Phagocytes are a type of white blood cell.) Children with these disorders have frequent severe infections that require hospitalization, sometimes for long periods of time. Many of them also have problems with school, learning, behavior, anxiety and depression. This study will explore whether these latter problems are a direct result of the illness itself or are a consequence of frequent, long hospitalizations, or are due to other factors. Test findings in these children will be compared with those of children with cystic fibrosis-another disease that causes frequent infections requiring prolonged hospitalization.
Patients age 2 or older with GCD or other phagocytic disorders or cystic fibrosis may be eligible for this study. Participants (or a parent or guardian) will complete questionnaires including personal information such as age, gender and marital status, a family medical history, and information on their illness. Patients will be given various psychological and intelligence tests, and they and their parents or guardians will be interviewed by a child psychiatrist. The tests and interviews take a total of about 5 hours and are given in two or three separate sessions.
The tests may reveal problems such as learning disorders, attention-deficit hyperactivity disorder, anxiety, or depression. If any of these problems are identified, appropriate referrals will be made for specialized services, such as special school placement, tutoring, or counseling.
- Sponsoring Institute:
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National Institute of Allergy and Infectious Diseases (NIAID)
- Recruitment Detail
- Type:
Active Accrual Of New Subjects
- Gender:
Male & Female
- Referral Letter Required:
Yes
- Population Exclusion(s):
None
- Eligibility Criteria:
INCLUSION CRITERIA
Presence of a confirmed diagnosis of CGD or other phagocytic disorder.
Age 2 or older.
English spoken in the home.
EXCLUSION CRITERIA
Unconfirmed phagocytic disorder.
Under age 2.
First language is other than English.
- Special Instructions:
Currently Not Provided
- Keywords:
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Chronic Disease
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Pediatric
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Pulmonary
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Intelligence
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Coping
- Recruitment Keywords:
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Chronic Illness
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Learning
- Conditions:
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Chediak Higashi Syndrome
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Chronic Granulomatous Disease
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Job's Syndrome
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Leukocyte Disorder
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Contacts:
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Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citations:
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Mental retardation
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Emotional adjustment of adolescents and young adults with cystic fibrosis
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Genetics of childhood disorders: XI Fragile X Syndrome
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Warren Grant Magnuson Clinical Center (CC) National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/19/2004
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