NIH Clinical Research Studies

Protocol Number: 00-M-0049

Active Accrual, Protocols Recruiting New Patients

Title:
Factors in Susceptibility to Ischemic Heart Disease in Major Depression: Documentation of Insulin Resistance in Patients with Major Depression Utilizing the Hyperinsulinemic Euglycemic Glucose Clamp
Number:
00-M-0049
Summary:
The purpose of this study is to understand why depressed people have a greater chance of developing heart disease than people who are not depressed. This study will examine insulin resistance in participants with major depression to determine how severe it is and why it occurs.

People with major depression have an increased risk for coronary artery disease. This increased risk may be a result of hormonal changes that occur with depression. Insulin resistance may be associated with these hormonal changes. This study will determine whether insulin resistance is an underlying mechanism that predisposes people with major depression to ischemic heart disease.

Participants will be screened with a medical and psychiatric history, a physical examination, blood and urine tests, and an electrocardiogram. A control group of healthy volunteers will also be recruited as a comparison group.

Sponsoring Institute:
National Institute of Mental Health (NIMH)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): None

Eligibility Criteria:
INCLUSION CRITERIA:

Men and women, from all ethnic backgrounds, between 18 and 65 years old who have had a history of any types of major depression or are currently depressed will be eligible for this study, provided they are free from the conditions described in the exclusion criteria. Candidates will be screened with a complete medical and psychiatric history and physical examination, as well as blood and urine tests, and electrocardiogram. Healthy volunteers will also be recruited to this study to serve as a control group. Volunteers will be matched to each patient in the study according to age, gender, body weight and height, and will undergo the same screening and study procedures.

Females must not be pregnant.

Subjects must not have diabetes mellitus.

Subjects must not have cardiovascular, renal, hepatic and other end organ diseases.

Subjects must not have peripheral vascular disease.

Subjects must not have any inflammatory diseases.

Subjects must not have HIV infection.

Subjects must not be on beta-blockers, thiazides, and/or glucocorticoids.

Subjects must have BMI of 29 or less.

Special Instructions: Currently Not Provided
Keywords:
Cardiovascular Disease
Glucose Clamp
Hypercortisolism
Insulin Sensitivity
Major Depression Disorder
Recruitment Keywords:
Depression
Volunteer
Healthy Volunteer
Conditions:
Adrenal Gland Hyperfunction
Cardiovascular Disease
Involutional Depression
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patricia M. Kasdan
National Institutes of Health
Building 10
Room 3S235A
10 Center Drive
Bethesda, Maryland 20892
Phone: (301) 496-7290
Fax: Not Listed
Electronic Address: kasdanp@mail.nih.gov

Citations:
Depression and long-term mortality risk in patients with coronary artery disease

Depression and the course of coronary artery disease

Depression and the dynamics of smoking A national perspective

Active Accrual, Protocols Recruiting New Patients

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