Protocol Number: 01-I-0153
CVID patients with gastrointestinal symptoms 10 years of age and older may be eligible for this study; CVID patients without gastrointestinal symptoms 18 years of age and older will be enrolled as control subjects. Candidates will be screened with a review of their medical records, a medical history and physical examination, HIV blood test, stool sample, and hydrogen breath test. The breath test measures the amount of hydrogen in the breath after drinking sugar water, showing the digestive effects of bacteria in the upper intestine. Participants will be admitted to the NIH Clinical Center for several days to undergo the following procedures: - Medical history and physical examination - Blood tests - Urine and stool samples - 48-hour stool fat collection - measures the amount of undigested fat in the stool to determine the ability of the gut to digest and absorb fat in the diet - D-Xylose absorption test - measures the ability of a sugar compound to travel across the lining of the intestine to determine the ability of the gut to absorb nutrients - Upper endoscopy - a thin flexible lighted tube is advanced through the mouth to evaluate the esophagus, stomach and beginning of the small intestine - Lower endoscopy - a thin lighted tube is advanced through the rectum to evaluate the colon Identification of GI abnormalities associated with changes in immune response in CVID patients will help in developing and testing new treatments for this disease.
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Warren Grant Magnuson Clinical Center (CC) |
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