INCLUSION CRITERIA:
Patients of all ages and their families with known or suspected inherited neurological disorders will be considered as potential candidates for this study. In particular, families with more than one affected relative will be sought.
Movement disorders to be studied include but are not limited to Parkinson's disease, spinocerebellar ataxias, hereditary tremor and myoclonus.
Pregnant women will be included except for tests involving radiation or anesthesia.
Referrals will be accepted from geneticists, genetic counselors, neurologists and other health care providers and family members who express interest in participating when sufficient clinical and/or laboratory diagnostic evidence is available.
Medical records that support the diagnosis will be requested and evaluated by the principal investigator and his associates. Those identified to meet diagnostic criteria, will be invited to the NIH for evaluation.
Some family members may choose not to travel to the NIH for the clinical component of this project, but may choose to participate in the registry and tissue analysis aspects of this research project.
Appropriateness for inclusion in the protocol will be considered after medical record review and discussion with the referring health care provider.
The general health and well being of each potential participant must be sufficient to allow for travel to the NIH, blood drawing, and as indicated, pulmonary and cardiac evaluations, physical therapy assessments, and other routine diagnostic procedures.
Patients will be enrolled without regard to race, creed, color, religion, or national origin.
EXCLUSION CRITERIA:
Pregnant women will be included except for tests involving radiation or anesthesia.