Protocol Number: 02-C-0017

Title:

Biological Specimen Collection for Laboratory Methods Development and for Training Purposes

Number:

02-C-0017

Summary:

This study will collect biological samples-buccal cells, blood sample, skin sample-to be used in developing and testing laboratory methods for measuring and analyzing genes. Such methods can be used for research on identifying genetic factors that may affect a person's cancer risk.

All individuals age 21 and older may participate in this study. Participants will provide one or more of the following samples:

- Buccal (mouth) cells - obtained by swishing a small amount of mouthwash in the mouth or by swabbing or bushing the inside of the cheek with a swab or brush.

- Blood - obtained by pricking the finger and collecting the drops or by blood drawing through a needle placed in an arm vein.

- Skin - obtained by a punch biopsy on the inner upper arm. For this procedure, the skin is anesthetized and a small piece of skin is removed with a sharp instrument similar to a cookie cutter. The wound is then covered and held together with a sterile bandage. A small scar, approximately 1/8-inch long, will be left.

Most participants will be asked to provide only a buccal sample; blood and/or skin samples will be requested from a few participants. The blood and skin samples may be used to grow cell lines; that is, to make them grow indefinitely for research uses.

Sponsoring Institute:

National Cancer Institute (NCI)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

All individuals age 21 and older will be eligible.

EXCLUSION CRITERIA:

Participants who have volunteered for previous DCEG studies within the past three years in which buccal or blood samples were collected will be excluded because the samples collected in the current study may be combined with some previously collected samples and duplication of subjects is to be avoided.

Individuals with known active oral disease will be excluded from the buccal cell collection component, and those known to form keloids will be excluded from the skin biopsy component.

Special Instructions: Currently Not Provided

Keywords:

Buccal

DNA

Pooling

Genotyping

Mouthwash

Recruitment Keywords:

Healthy Volunteer

HV

Normal Control

Conditions:

Healthy

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

CSSC
Clinical Studies Support Center/NCI
164 Rollins Avenue
2nd FLoor
Rockville, MD 20852
Phone: (888) 624-1937
Fax: (301) 881-8239

Electronic Address: ncicssc@mail.nih.gov

Citations:

Self-collection of oral epithelial cell DNA under instruction from epidemiologic interviewers

Collection of buccal cell DNA using treated cards

High-throughput development and characterization of a genomewide collection of gene-based single nucleotidepolymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/20/2004