Protocol Number: 02-C-0178
People with a family history of testicular cancer-defined as at least two cases of testicular cancer in blood relatives or a single family member with cancer in both testicles-may be eligible for this study. Those enrolled may participate in part 1 or parts 1 and 2 of this two-part study. Participants will undergo the tests and procedures described below. Part 1 - Genetic Study - Provide a blood or cheek cell sample to obtain DNA (hereditary material) for testing to identify genes related to the inherited form of testicular cancer. No more than 40 milliliters (about 3 tablespoons) of blood will be collected. Cheek cells will be collected by swishing a mouthwash and spitting into a container. Blood samples (DNA, serum, plasma) will be stored for future laboratory research aimed at reaching a better understanding of the causes of familial testicular cancer. - Fill out questionnaires providing information about: 1) personal and family medical history; 2) exposure to various factors that might influence the risk of testicular cancer; and 3) mood, attitudes and feelings related to being a member of a family in which several relatives have developed testicular cancer. - Give permission to obtain past medical records and pathology material related to cancer and related illnesses, and give permission to obtain medical records and pathology materials from deceased relatives for whom the participant is the next of kin or legally authorized representative. Part 2 - Clinical Evaluation - All participants: medical history and routine tests, such as blood drawing. - All adults: complete physical examination; computed tomography (CT) scan of the chest, abdomen and pelvis. CT uses x-rays to produce images of the kidneys, bladder, lungs, and other internal organs. - Males: examination of the testicles and scrotum; ultrasound (test that uses sound waves to produce images) of the testicles and scrotum; and semen sample (in men ages 18 and above) to check for measures of fertility. - Females: pelvic examination to check the ovaries, uterus and fallopian tubes.
Search The Studies | Help | Questions |
Warren Grant Magnuson Clinical Center (CC) |
||