Protocol Number: 02-C-0179

Title:

Collection of Blood from Patients with Cancer

Number:

02-C-0179

Summary:

This study will collect blood from patients with cancer to study the level of cells which decrease the immune response (suppressor cells) before and after chemotherapy. Patients 18 years of age and older with cancer may participate. This study does not involve treatment.

Participants will have about 50 ml (3 tablespoonfuls) of blood drawn. Depending on their condition, patients may be invited to enroll in a clinical research study involving chemotherapy, radiotherapy, or surgery. Additional 40-ml blood samples may be drawn during the course of treatment.

Sponsoring Institute:

National Cancer Institute (NCI)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

Patients 18 years of age and older are eligible.

Patients must have a performance status of ECOG 0,1, 2, or 3 for admission to this protocol.

Patients with malignancy are eligible.

EXCLUSION CRITERIA:

Children will not be eligible.

Special Instructions: Currently Not Provided

Keywords:

Suppressor Cells

T Cells

CD4+/CD25+ Cells

Recruitment Keywords:

Cancer

Malignancy

Blood Sample

Conditions:

Neoplasms

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

CSSC
Clinical Studies Support Center/NCI
164 Rollins Avenue
2nd FLoor
Rockville, MD 20852
Phone: (888) 624-1937
Fax: (301) 881-8239

Electronic Address: ncicssc@mail.nih.gov

Citations:

Shimizu J, Yamazaki S, Sakaguchi S Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity J Immunol 1999 Nov 15;163(10):5211-8 PMID: 10553041

Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolatedfrom peripheral blood J Exp Med 2001 Jun 4;193(11):1285-94PMID: 11390435

Levings MK, Sangregorio R, Roncarolo MG Related Articles Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitrowithout loss of functionJ Exp Med 2001 Jun 4;193(11):1295-302PMID: 11390436

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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/21/2004