Protocol Number: 02-C-0226

Title:

Are the Proteomic Profiles of Serum and Urine Predictive for Clinical Outcome After Definitive Radiotherapy for Localized Prostate Cancer? A Preliminary Cohort Study

Number:

02-C-0226

Summary:

This study will examine whether proteins in the blood or urine can indicate the response to radiation therapy for localized prostate cancer. The results may help researchers determine the potential gain from improvements in radiotherapy and identify which patients may or may not benefit from aggressive treatment.

Patients with localized prostate cancer who will have or have had radiation therapy to treat their disease may be eligible for this study.

Participants will give a medical history and undergo a physical examination, including a digital rectal examination, determination of prostate-specific antigen (PSA) level, and in some cases, a bone scan. They will provide a urine sample and a blood sample. The samples will be used to identify what proteins are present in the blood and urine of men with prostate cancer and whether these proteins differ in men 1) who have not yet been treated for their disease, 2) who are free of disease after radiation therapy, and 3) whose prostate cancer has recurred

Sponsoring Institute:

National Cancer Institute (NCI)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male

Referral Letter Required: No

Population Exclusion(s): Female

Children

Eligibility Criteria:

INCLUSION CRITERIA

Patients with a history of localized prostate cancer prior to, or having completed, definitive radiotherapy.

EXCLUSION CRITERIA

Inability to provide informed consent.

Patient who have unobtainable data regarding previous therapy and/or clinical outcome.

Special Instructions: Currently Not Provided

Keywords:

Radiation

Prostate Cancer

Protein Profile

Blood Collection

Urine Collection

Recruitment Keywords:

Prostate Cancer

Conditions:

Prostatic Neoplasms

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:

Greenlee RT, et al Cancer statistics, 2001[PMID:11577478]

Crook JM, et al Routine prostate biopsies fol[PMID:7716843]

Petricoin EF, et al Use of proteomic patterns in [PMID:11867112]

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/16/2004