NIH Clinical Research Studies

Protocol Number: 02-D-0169

Active Accrual, Protocols Recruiting New Patients

Title:
Complex Regional Pain Syndrome Proteomics Study
Number:
02-D-0169
Summary:
This study will try to learn more about complex regional pain syndrome, or CRPS (previously known as reflex sympathetic dystrophy, spreading neuralgia, and sympathalgia), by examining the release of small proteins in the blood of patients with this condition. Patients with CRPS usually have three types of symptoms:

- Sensory abnormalities - increased sensitivity to pain or a painful reaction to a harmless stimulus

- Perfusion abnormalities - alterations in blood flow, temperature abnormality, swelling, decrease or increased nail growth, and hair and skin changes

- Motor abnormalities - weakness, guarding (Holding the limb in such a fashion that it minimizes accidental or intentional contact from possible sources of pain), and atrophy (wasting)

The cause of CRPS is unknown, and there are no definitive diagnostic tests for the condition. Because early treatment improves the prognosis of CRPS, a test that enables early diagnosis would be important for optimal medical management. The findings of this study may contribute to the development of such a test and possibly new drug treatments.

Normal healthy volunteers and patients of any age with complex regional pain syndrome who are in otherwise good general health may be eligible for this study.

Participants will have a medical history, physical examination and collection of a blood sample. They will fill out several questionnaires, providing information on their health, personality, mood, pain levels, and symptoms. Participation in the study requires one outpatient clinic visit.

Sponsoring Institute:
National Institute of Dental And Craniofacial Research (NIDCR)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: Yes
Population Exclusion(s): None

Eligibility Criteria:
INCLUSION CRITERIA

Male or female volunteers referred by their physician with the diagnosis of CRPS

Age restrictions: none

Good general health

Willing to have blood drawn

Willing to have behavioral measures

Willing to provide a directed medical history

There is expected to be a greater number of females than males being recruited to this study since there is a much higher occurrence of CRPS in women. Additionally, it is expected to be equal across all ethnic groups. However, we do not anticipate requiring any special recruiting strategies for specific gender or ethnic groups.

EXCLUSION CRITERIA

Contradiction to blood screening

Advanced disease other than the CRPS (cardiovascular, liver, kidney disease-ASA III or above excluding CRPS) that may cause a theoretical inclusion of samples resulting in confounding results.

No exclusions will be made based on race, gender, or religion.

Special Instructions: Currently Not Provided
Keywords:
CRPS
RSD
Causalgia
Chronic Pain
Neuropathic Pain
Recruitment Keywords:
Normal Control
Complex Regional Pain Syndrome
CRPS
RSD
Healthy Volunteer
HV
Conditions:
Complex Regional Pain Syndromes
Healthy
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Bichsel VE, Liotta LA, Petricoin EF 3rd Cancer proteomics: from biomarker discovery to signal pathway profiling Cancer J 2001 Jan-Feb;7(1):69-78 Review PMID: 11269650

Bittner M, Molecular classification of cutaneous malignant melanoma by gene expression profiling Nature 2000 Aug 3;406(6795):536-40 PMID: 10952317

Chelimsky TC, Low PA, Naessens JM, Wilson PR, Amadio PC, O'Brien PC Value of autonomic testing in reflex sympathetic dystrophy Mayo Clin Proc 1995 Nov;70(11):1029-40 PMID: 7475332

Active Accrual, Protocols Recruiting New Patients

If you have:


Command Menu Bar

Search The Studies | Help | Questions |
Clinical Center Home | NIH Home


Clinical Center LogoWarren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/15/2004

Search The Studies Help Questions