Protocol Number: 02-N-0011

Title:

EEG Analysis of Ideomotor Apraxia

Number:

02-N-0011

Summary:

This study will examine how the brain operates during execution and control of voluntary movement and what goes wrong with these processes in disease. It will use electroencephalography (EEG) and electromyography (EMG) to compare brain function in normal subjects and in patients with-a disorder affecting patients with stroke and other brain lesions. These patients have problems with timing, sequence and spatial organization of certain types of movements.

EEG measures the electrical activity of the brain. The activity is recorded using wire electrodes attached to the scalp or mounted on a Lycra cap placed on the head. EMG measures electrical activity from muscles. It uses wire electrodes placed on the skin over the muscles.

Adult healthy normal volunteers and patients with ideomotor apraxia with a single left brain lesion may be eligible for this study.

Study participants will be asked to make certain movements with their arms or hands, such as waving and using scissors. Brain and muscle activity will be measured during these tasks with EEG and EMG recordings. Patients may be asked to repeat these tests over time as their condition changes (such as during recovery from a stroke) to gain information about the recovery process.

Sponsoring Institute:

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria:

INCLUSION CRITERIA

Normal subjects.

Patients diagnosed with Ideomotor apraxia with a single left hemisphere lesion.

Patients with Ideomotor apraxia with corticobasal ganglionic degeneration.

EXCLUSION CRITERIA

Normal subjects: abnormal neurologic examination or history of neurologic disorders.

Ideomotor apraxic patients: a second neurologic disorder including more than one brain lesion or the inability to cooperate fully.

Normal and Ideomotor apraxic patients: cognitively impaired subjects will not be accrued (for the purposes of this study, patients that can provide full informed consent for the study are not considered cognitively impaired).

For MRI studies, patients with metallic implants to remove potential risks from this procedure.

For MRI purposes, women who are pregnant are excluded from this part of the protocol. Therefore, all women of childbearing potential will have a pregnancy test performed, which must be negative, before proceeding.

Special Instructions: Currently Not Provided

Keywords:

Movement

Coordination

Correlation

Coherence

Parietofrontal Circuitry

Recruitment Keywords:

Apraxia

Ideomotor Apraxia

Healthy Volunteer

HV

Normal Control

Conditions:

Ideomotor Apraxia

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:

Post operative supplementary motor area syndrome: clinical features and outcome

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/23/2004