NIH Clinical Research Studies

Protocol Number: 02-N-0068

Active Accrual, Protocols Recruiting New Patients

Title:
Comparison of Externally and Self-Initiated Movements
Number:
02-N-0068
Summary:
This study will use magnetic resonance imaging (MRI) to investigate how the brain controls voluntary movements triggered by an external stimulus or self-initiated.

Registered HCMS healthy normal volunteers may participate. They will complete a questionnaire and will have a medical history and brief physical examination.

The study consists of two parts: 1) body movement training and 2) magnetic resonance imaging, as follows:

Part 1 - Body movement training

Participants will train to do three different body movements involving the hands and feet. The movements will either be self-initiated or in response to a stimulus, such as a visual or auditory trigger.

Part 2 - Magnetic resonance imaging

Participants will do one or more of the trained movements, with or without a triggering stimulus, during MRI scanning. MRI is a diagnostic procedure that uses a magnetic field and radio waves to produce images of brain structure and activity. For the procedure, the subject lies on a stretcher that is moved into the scanner-a cylinder containing a strong magnet. Earplugs are worn to protect the ears from loud thumping noises that occur with electrical switching of radio frequency circuits. Scanning time varies from 20 minutes to 2 hours, with most examinations lasting 1 to 1-1/2 hours. The subject can communicate with the staff person conducting the test at all times during the scan. A device compatible with magnetic resonance will be used to record the participant's body movements. The participant may be asked to push buttons of the device during the tasks.

Sponsoring Institute:
National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): Children

Eligibility Criteria:
INCLUSION CRITERIA:

Normal volunteers will be included. Normal volunteers will be recruited from people who are registered as HMCS Normal Volunteers. All subjects participating in MR studies should have a valid Clinical Center Medical Record Number.

EXCLUSION CRITERIA:

We will not scan pregnant women because safety of high magnetic field to fetus is not established. Therefore, we will administer a urine pregnancy test for any female subjects of childbearing potential prior to functional MRI scan. If the result from a urine pregnancy test is not available for some reason, a medical doctor will judge based on the proper information prior to the scanning.

Special Instructions: Currently Not Provided
Keywords:
Voluntary Movement
Functional MRI
Sensorimotor Integration
Superior Parietal Lobe
Supplementary Motor Area
Recruitment Keywords:
Normal Control
HV
Voluntary Movement
Healthy Volunteer
Conditions:
Healthy
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Alexander GE, Crutcher MD Neural representations of the target (goal) of visually guided arm movements in three motor areas of the monkey J Neurophysiol 1990 Jul;64(1):164-78PMID: 2388063

Brinkman C, Supplementary motor area and premotor area of monkey cerebral cortex: functional organization and activities of single neurons during performance of a learned movementAdv Neurol 1983;39:393-420 PMID: 6419554

Burbaud P, Doegle C, Gross C, Bioulac B A quantitative study of neuronal discharge in areas 5, 2, and 4 of the monkey during fast arm movements J Neurophysiol 1991 Aug;66(2):429-43PMID: 1774580

Active Accrual, Protocols Recruiting New Patients

If you have:


Command Menu Bar

Search The Studies | Help | Questions |
Clinical Center Home | NIH Home


Clinical Center LogoWarren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/16/2004

Search The Studies Help Questions