|
Protocol Number:
02-N-0068
- Title:
Comparison of Externally and Self-Initiated Movements
- Number:
02-N-0068
- Summary:
This study will use magnetic resonance imaging (MRI) to investigate how the brain controls voluntary movements triggered by an external stimulus or self-initiated.
Registered HCMS healthy normal volunteers may participate. They will complete a questionnaire and will have a medical history and brief physical examination.
The study consists of two parts: 1) body movement training and 2) magnetic resonance imaging, as follows:
Part 1 - Body movement training
Participants will train to do three different body movements involving the hands and feet. The movements will either be self-initiated or in response to a stimulus, such as a visual or auditory trigger.
Part 2 - Magnetic resonance imaging
Participants will do one or more of the trained movements, with or without a triggering stimulus, during MRI scanning. MRI is a diagnostic procedure that uses a magnetic field and radio waves to produce images of brain structure and activity. For the procedure, the subject lies on a stretcher that is moved into the scanner-a cylinder containing a strong magnet. Earplugs are worn to protect the ears from loud thumping noises that occur with electrical switching of radio frequency circuits. Scanning time varies from 20 minutes to 2 hours, with most examinations lasting 1 to 1-1/2 hours. The subject can communicate with the staff person conducting the test at all times during the scan. A device compatible with magnetic resonance will be used to record the participant's body movements. The participant may be asked to push buttons of the device during the tasks.
- Sponsoring Institute:
-
National Institute of Neurological Disorders and Stroke (NINDS)
- Recruitment Detail
- Type:
Active Accrual Of New Subjects
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
INCLUSION CRITERIA:
Normal volunteers will be included. Normal volunteers will be recruited from people who are registered as HMCS Normal Volunteers. All subjects participating in MR studies should have a valid Clinical Center Medical Record Number.
EXCLUSION CRITERIA:
We will not scan pregnant women because safety of high magnetic field to fetus is not established. Therefore, we will administer a urine pregnancy test for any female subjects of childbearing potential prior to functional MRI scan. If the result from a urine pregnancy test is not available for some reason, a medical doctor will judge based on the proper information prior to the scanning.
- Special Instructions:
Currently Not Provided
- Keywords:
-
Voluntary Movement
-
Functional MRI
-
Sensorimotor Integration
-
Superior Parietal Lobe
-
Supplementary Motor Area
- Recruitment Keywords:
-
Normal Control
-
HV
-
Voluntary Movement
-
Healthy Volunteer
- Conditions:
-
Healthy
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Contacts:
-
Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citations:
-
Alexander GE, Crutcher MD Neural representations of the target (goal) of visually guided arm movements in three motor areas of the monkey J Neurophysiol 1990 Jul;64(1):164-78PMID: 2388063
-
Brinkman C, Supplementary motor area and premotor area of monkey cerebral cortex: functional organization and activities of single neurons during performance of a learned movementAdv Neurol 1983;39:393-420 PMID: 6419554
-
Burbaud P, Doegle C, Gross C, Bioulac B A quantitative study of neuronal discharge in areas 5, 2, and 4 of the monkey during fast arm movements J Neurophysiol 1991 Aug;66(2):429-43PMID: 1774580
If you have:
Search The Studies | Help | Questions | Clinical Center Home | NIH Home
Warren Grant Magnuson Clinical Center (CC) National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/16/2004
|
|