NIH Clinical Research Studies

Protocol Number: 02-N-0109

Active Accrual, Protocols Recruiting New Patients

Title:
Real-time Analysis of Scalp Electroencephalography During Production of Human Voluntary Movement
Number:
02-N-0109
Summary:
This study will use electroencephalography (EEG) to examine how the brain prepares for movement. It will look at 1) what changes occur in a person's brain just before voluntary movement, 2) when the changes occur, 3) how consistent the changes are, and 4) how the changes vary from person to person. The information from this study will be applied to other studies, such as exploring how brain changes that signal movement can be used to control prostheses in patients with spinal cord injuries or stroke.

Healthy normal volunteers 18 years of age and older may be eligible for this study. People with neurologic or psychiatric disorders and people taking medicines that may affect brain signals (e.g., Valium) may not participate.

Participants will come to the NIH Clinical Center on two separate days for testing sessions of 2 to 3 hours each. At each session, an EEG cap will be placed on the head to record brain signals, and electrodes will be placed on the arms to record movement. Subjects will perform simple movements during the EEG recording, such as flexing their arm of clenching their fist. Researchers will use the first recording to determine the pattern of how the brain prepares for movement. During the second recording, they will try to predict the subjects' movements, based on the patterns discerned in the first recording.

Sponsoring Institute:
National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): Children

Eligibility Criteria:
INCLUSION CRITERIA:

Healthy normal volunteers over age 18.

EXCLUSION CRITERIA:

Subjects on any medication that may effect the EEG such as benzodiazepines or antiepileptic medications.

Subjects who are unable to perform simple voluntary movement of both hands.

Subjects who have any neurologic or psychiatric condition.

Special Instructions: Currently Not Provided
Keywords:
Preparation
Subconscious
Recruitment Keywords:
Healthy Volunteer
HV
Normal Control
Conditions:
Healthy
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Cohen LG, Bandinelli S, Sato S, Kufta C, Hallett M Attenuation in detection of somatosensory stimuli by transcranial magneticstimulation Electroencephalogr Clin Neurophysiol 1991 Oct;81(5):366-76 PMID: 1718723

Guger C, Ramoser H, Pfurtscheller G Real-time EEG analysis with subject-specific spatial patterns for a brain-computer interface (BCI) IEEE Trans Rehabil Eng 2000 Dec;8(4):447-56 PMID: 11204035

Haggard P, Eimer M On the relation between brain potentials and the awareness of voluntary movements Exp Brain Res 1999 May;126(1):128-33 PMID: 10333013

Active Accrual, Protocols Recruiting New Patients

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