NIH Clinical Research Studies

Protocol Number: 02-N-0135

Active Accrual, Protocols Recruiting New Patients

Title:
A Neuroimaging Study of Automatic Movements
Number:
02-N-0135
Summary:
This study uses magnetic resonance imaging (MRI) to explore the brain activities involved in performing learned automatic movements. Automatic movements are performed without concentrating on the details of the movement.

Healthy adult volunteers are eligible for this study. Candidates will have a medical history and brief physical examination and will fill out a questionnaire. Women of childbearing potential will have a urine pregnancy test. Pregnant women will not be enrolled.

Participants will perform certain tasks involving movement of the right or left hand while undergoing MRI scanning. They will undergo scanning twice-before and after practicing the movement tasks. Before the second scan, participants will practice the following tasks for 1 week:

- Tapping task - subjects use their left index finger to tap a button at a certain frequency.

- Sequential movement task - subjects perform sequential finger-tapping movements with their right hand, in which they tap buttons with their fingers at a certain frequency in a 25-second period. There are two sequences of different lengths, referred to as sequence-4 and sequence-12, based on the number of movements in each unit of the sequence.

- Visual distraction task - 14-letter sequences consisting of the letters A, G, L, and O will be presented and subjects will be asked to identify the number of times they see a target letter.

- Dual tasks - after completing all the above tasks, subjects perform the following dual tasks:

Tapping and visual task

Sequence-4 finger tap and visual task

Sequence-12 finger tap and visual task

Tapping and sequence-4 finger tap

Tapping and sequence-12 finger tap

When the participants can perform the dual tasks correctly 90 percent of the time, the movements will be considered automatic, and the subjects will undergo MRI scanning. MRI uses a magnetic field and radio waves to produce images of the brain. For the procedure, the subject lies still on a stretcher that is moved into the scanner (a narrow cylinder containing the magnet). Earplugs are worn to muffle loud noises caused by electrical switching of radio frequency circuits used in the scanning process. The scan will last about 1.5 hours.

Sponsoring Institute:
National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): Children

Eligibility Criteria:
INCLUSION CRITERIA:

Forty normal adult volunteers will be included. Volunteers will be recruited from people who are registered as HMCS Normal Volunteers. All subjects participating in MR studies should have a valid Clinical Center Medical Record Number. Procedures for the functional fMRI experiment will follow the Standard Operating Procedures of HMCS Neuroimaging group.

EXCLUSION CRITERIA:

Subjects with pacemakers, cardiac, or neural defibrillators, intracranial aneurysm clips, intraorbital metallic structures, insulin pumps, cochlear implants, and other metallic objects will not be scanned. We will not scan pregnant women because the safety of high magnetic fields to the fetus is not established. Therefore, we will administer a urine pregnancy field for any female of childbearing potential prior to functional MRI scan. If the result from a urine pregnancy test is not available for some reason, a medical doctor will judge based on the proper information prior to the scanning. We will also exclude children because the study will be too complex for them.

Special Instructions: Currently Not Provided
Keywords:
Functional MRI
Dual Task
Neural Activation
Basal Ganglia
Cerebellum
Recruitment Keywords:
Healthy Volunteer
HV
Normal Control
Conditions:
Healthy
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Brown P, Marsden CD What do the basal ganglia do?Lancet 1998 Jun 13;351(9118):1801-4 Review PMID: 9635969

Catalan MJ, Honda M, Weeks RA, Cohen LG, Hallett M The functional neuroanatomy of simple and complex sequential finger movements: aPET studyBrain 1998 Feb;121 ( Pt 2):253-64 PMID: 9549504

Jueptner M, Weiller C A review of differences between basal ganglia and cerebellar control of movements as revealed by functional imaging studiesBrain 1998 Aug;121 ( Pt 8):1437-49 Review PMID: 9712006

Active Accrual, Protocols Recruiting New Patients

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