NIH Clinical Research Studies

Protocol Number: 02-N-0199

Active Accrual, Protocols Recruiting New Patients

Title:
Functional Coupling Of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control
Number:
02-N-0199
Summary:
This study examines the relationship between a cerebral hemisphere and control of muscles on the same side of the body (ipsilateral control). One good way to study this relationship is to record electroencephalogram (EEG) activity directly from the cortical surface. Because patients with epilepsy who are surgical candidates are already undergoing monitoring with subdural and/or depth electrodes, they present an opportunity to study ipsilateral control. Studying the electrocorticographic (ECoG) activity associated with simple voluntary movement in such patients would not disturb ongoing monitoring of nearby areas of the brain, nor would it endanger the patients.

Ten patients, who may be children or adults, will be recruited for this study. Brain activity will be measured while they move the corner of their mouth and their fingers, wrists, arms, and feet. The baseline measurements will be done with scalp electrodes. Once subdural electrodes have been placed, a second set of measurements will be done. Surface EMG electrodes will be placed on the muscles whose movements are being tested. The tests will be done on no more than 3 separate days, in sessions no longer than 2 hours, for each patient.

Sponsoring Institute:
National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: Yes
Population Exclusion(s): None

Eligibility Criteria:
INCLUSION CRITERIA:

PATIENTS UNDERGOING SUBDURAL IMPLANTATION:

Epileptic patients who are undergoing invasive recording with implanted subdural electrodes that cover the sensorimotor cortices.

Therefore, we will recruit only those patients with medically intractable epilepsy who are candidates for surgical treatment, and in whom invasive monitoring was deemed necessary for the purpose of precise localization of epileptogenic zones.

PATIENTS UNDERGOING AWAKE CRANIOTOMY:

Only adult (18 years and older) patients will be recruited for the awake craniotomy study.

The patient must understand the nature of the study and must be able to cooperate with the requirements of and tolerate an awake craniotomy for functional mapping.

EXCLUSION CRITERIA:

EPILEPTIC PATIENTS:

Patients whose electrode implantation does not cover the sensorimotor cortices.

PATIENTS UNDERGOING AWAKE CRANIOTOMY:

Patients whose tumor or other brain lesion(s) do not require mapping of the motor and sensory and supplemental cortex regions via an awake cramiotomy.

Special Instructions: Currently Not Provided
Keywords:
Subdural
Epilepsy
Motor Function
Desynchronization
Coherence
Motor Control
Recruitment Keywords:
Epilepsy
Conditions:
Epilepsy
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Andrew C, Pfurtscheller G Event-related coherence as a tool for studying dynamic interaction of brainregions Electroencephalogr Clin Neurophysiol 1996 Feb;98(2):144-8 PMID: 8598174

Conway BA, Halliday DM, Farmer SF, Shahani U, Maas P, Weir AI, Rosenberg JR Synchronization between motor cortex and spinal motoneuronal pool during theperformance of a maintained motor task in man J Physiol 1995 Dec 15;489 ( Pt 3):917-24 PMID: 8788955

Bartolomei FSeizures of temporal lobe epilepsy: identification of subtypes by coherenceanalysis using stereo-electro-encephalography Clin Neurophysiol 1999 Oct;110(10):1741-54 PMID: 10574289

Active Accrual, Protocols Recruiting New Patients

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