Protocol Number: 03-I-0310
HIV-infected patients and healthy normal volunteers between 18 and 60 years of age may be eligible for this study. Healthy subjects will serve as controls to make sure the flu vaccine works (i.e., stimulates production of enough antibody to protect against the flu), and to compare the amount of antibodies made by HIV-positive and HIV-negative people. Candidates will be screened with a medical history and blood tests (see below). Women who are able to have children will have a pregnancy test. Pregnant women are excluded from the study. Participants will undergo the following procedures: 1) Blood drawing for the following tests: - Routine tests (complete blood count, kidney and liver functions, electrolyte levels). - CD4 cell count. - HLA typing (a genetic marker of the immune system) if it has not already been done at the NIH. This test may be used to try to identify factors associated with the rate of progression of HIV disease or related conditions. Determining HLA type is necessary to be able to perform certain research studies. Some HLA types have been associated with an increased risk of certain diseases like arthritis and other rheumatologic problems. - Viral load (HIV-infected patients only). - Influenza antibody levels. - B cell levels. 2) Flu vaccination 3) Follow-up visits on days, 7, 28, and 54 after vaccination for the following: - Review of any illnesses or fever. - Review of medications, if any changes were made. - Repeat blood tests.
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Warren Grant Magnuson Clinical Center (CC) |
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