Protocol Number: 03-N-0230

Title:

Event-Related fMRI Analysis of Patients with Ideomotor Apraxia During Transitive and Intransitive Hand Gesturing

Number:

03-N-0230

Summary:

Ideomotor apraxia, a disorder that affects patients with stroke and a variety of other brain lesions, features disturbed timing, sequence, and spatial organization of skilled movements. This study will look at how different areas of the human brain control fine hand movements.

Thirty-five participants 21 years and older will be enrolled in this study-25 healthy, right-handed people, and 10 stroke patients. They will undergo two outpatient sessions, each lasting up to 3 hours. The first visit for the stroke patients will occur between 2 weeks and 3 months after the stroke; the second visit will be at least 6 months after the stroke.

Participants will have a physical exam, give a medical history, and complete a questionnaire. Then they will undergo magnetic resonance imaging (MRI) scans. They will lie in the MRI scanner and will be asked to do a number of skilled hand movements using the right hand (such as pretending to use a hammer or waving goodbye) in response to directions that will appear on a screen mounted over their head. Their movements will be recorded on videotape during the procedures.

Sponsoring Institute:

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria:

INCLUSION CRITERIA:

Normal volunteers will be recruited from people who are registered as HMCS normal volunteers.

Patients diagnosed with ideomotor apraxia with a single left hemisphere stroke will be included.

Lesions may be located in any part of the frontal and parietal areas or both, as well as their connections.

All subjects and patients participating in this study will have a valid Clinical Center Medical Record Number.

EXCLUSION CRITERIA:

Subjects with abnormal neurologic examinations, previous or current neurological and psychiatric disorders will be excluded.

Subjects under age 21, pregnant or mentally impaired will be excluded.

Ideomotor apraxic patients with a second neurologic disorder including more than one brain lesion of the inability to cooperate fully will be excluded.

Patients with a history of significant medical disorders such as cancers will be excluded.

MRI experiments will not be performed with subjects or patients who have pacemakers, brain stimulators, dental implants or metallic braces, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, insulin pumps, or shrapnel fragments.

Welders and metal workers are also at risk for injury because of possible small metal fragments in the eye of which they may be unaware. Subjects will be screened for these contraindications prior to the study.

Special Instructions: Currently Not Provided

Keywords:

Praxis Movements

Pantomime

Statistical Parametric Mapping

Functional Connectivity

Path Analysis

Recruitment Keywords:

Ideomotor Apraxia

Healthy Volunteer

HV

Conditions:

Ideomotor Apraxia

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:

Buhmann C, Glauche V, Sturenburg HJ, Oechsner M, Weiller C, Buchel C. Pharmacologically modulated fMRI--cortical responsiveness to levodopa in drug-naive hemiparkinsonian patients. Brain. 2003 Feb;126(Pt 2):451-61. PMID: 12538411

Choi SH, Na DL, Kang E, Lee KM, Lee SW, Na DG. Functional magnetic resonance imaging during pantomiming tool-use gestures. Exp Brain Res. 2001 Aug;139(3):311-7. PMID: 11545470

Haaland KY, Harrington DL, Knight RT. Neural representations of skilled movement. Brain. 2000 Nov;123 ( Pt 11):2306-13.

PMID: 11050030

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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