Protocol Number: 04-C-0199
-To define the molecular (genetic and protein) profile of normal breast tissue from pre- and post-menopausal women of different ages and who have had varying numbers of children (or no children), and who are in different phases of the menstrual cycle -To define the molecular profile of primary breast tumors and tumors that have metastasized (spread) beyond the primary site -To characterize breast cancer stem cells and establish cell lines from the pleural fluid (fluid around the lungs) of women with metastatic breast cancer. (A cell line is a collection of cells that are grown in the laboratory from an original tissue specimen.) The following women may be eligible for this study: -Women who are undergoing cosmetic breast surgery that requires removal of some breast tissue (e.g., breast reduction surgery) -Women 18 years of age or older who are undergoing a biopsy or other surgical procedure to sample or remove a known or suspected primary or metastatic breast tumor -Women 18 years of age or older who are undergoing pleurocentesis, a procedure to remove fluid from around the lung that is suspected or known to be caused by spread of breast cancer Participants undergo the required procedure (e.g., surgery, biopsy, or pleurocentesis) and provide information that may include the following: -Age, race/ethnicity -Age at first menstrual period (menarche) -Age at first pregnancy and age when the first child was born -Age at menopause -Information about primary breast cancer -Family history of breast cancer -Information on previous breast biopsies, if any, and hormones taken (birth control pills or hormone replacement therapy), if any -Copy of pathology report from procedure (surgery, biopsy, or pleurocentesis)
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