NIH Clinical Research Studies

Protocol Number: 04-CC-0237

Active Accrual, Protocols Recruiting New Patients

Title:
The Effects of Respiratory Motion on CT Based Attenuation Correction of Positron Emission Tomography Data: Liver and Heart Studies
Number:
04-CC-0237
Summary:
This study will determine how breathing motions may affect positron emission tomography (PET) scans. It has been discovered that the quality of PET scans varies according to which part of the breathing cycle patients hold their breath.

NIH Clinical Center patients 12 years of age and older who are scheduled to have PET and computed tomography (CT) scans as part of their standard medical care may be eligible for this study.

Participants have their scheduled PET or CT scan as they normally would and are asked to hold their breath after breathing out, as is usual. In addition, for this study, patients are also asked hold their breath after breathing in and again at a point between breathing in and out. Each breath-hold is for around 15 seconds. The scans for each of the three different breath-holds are examined for differences.

Some patients may also be asked to breathe through a tube called a pneumotachometer, or spirometer, to determine their normal breathing pattern. This involves breathing through a mouthpiece similar to a snorkel mouthpiece and takes about 2 minutes.

Sponsoring Institute:
Warren G. Magnuson Clinical Center (CC)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): None

Eligibility Criteria:
INCLUSION CRITERIA

Up to 30 subjects will take part in the study, chosen from sequential incoming clinical patients who are scheduled for PET/CT studies of the torso, without regard to disease. The number of subjects selected for study per week will depend on patient load and availability of scanner and technologist). Approximately an equal number of males and females will be selected by alternating each selection between male and female. The selection of subjects asked to participate will be random, in the sense that whenever technologist and analysis time is available, the next subject scheduled for a whole body scan will be asked to participate.

EXCLUSION CRITERIA

The only exclusion criteria will be subjects with respiratory difficulties.

Children under the age of 12.

Special Instructions: Currently Not Provided
Keywords:
Reconstruction
PET Artifacts
PET/CT Motion Artifacts
Recruitment Keywords:
Liver
Heart
Respiratory Motion
Conditions:
Healthy
Tomography
Emission Computed
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Beyer T, Antoch G, Blodgett T, Freudenberg LF, Akhurst T, Mueller S. Dual-modality PET/CT imaging: the effect of respiratory motion on combined image quality in clinical oncology. Eur J Nucl Med Mol Imaging. 2003 Apr;30(4):588-96. Epub 2003 Feb 12. PMID: 12582813

Goerres GW, Burger C, Kamel E, Seifert B, Kaim AH, Buck A, Buehler TC, Von Schulthess GK. Respiration-induced attenuation artifact at PET/CT: technical considerations. Radiology. 2003 Mar;226(3):906-10. PMID: 12616024

Osman MM, Cohade C, Nakamoto Y, Wahl RL. Respiratory motion artifacts on PET emission images obtained using CT attenuation correction on PET-CT. Eur J Nucl Med Mol Imaging. 2003 Apr;30(4):603-6. Epub 2003 Jan 21. PMID: 12536242

Active Accrual, Protocols Recruiting New Patients

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