Protocol Number: 04-DK-0021
Patients 18 to 65 years of age who are either healthy or have diabetes, have no major illnesses other than diabetes, have no serious complications of the disease and whose blood pressure is well controlled may be eligible for this study. Participants will choose to be studied either as outpatients or inpatients. They will undergo the following tests and procedures: -Medical history -Physical examination. -Blood and urine tests for complete blood count, vitamin C, various chemistries, hepatitis B, hepatitis C, HIV, cotinine and other tests. Participants will be asked to stop taking all vitamin preparations for 2 weeks before the study. Outpatients will provide a blood and urine sample after an overnight fast. The procedure will take a little over 1 hour. Inpatients will also provide a blood and urine sample, and afterward they will be hospitalized for 24 hours and placed on a diet free of vitamin C. They will be asked to eat and drink only food and beverages given to them during those 24 hours. A 24-hour urine sample will be collected for measurement of protein, creatinine, and vitamin C. Another blood sample will be collected on the morning of the second day, along with a sample of urine for vitamin C measurement.
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Warren Grant Magnuson Clinical Center (CC) |
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