NIH Clinical Research Studies

Protocol Number: 04-H-0213

Active Accrual, Protocols Recruiting New Patients

Title:
Cytokine Gene Polymorphisms in Bone Marrow Failure
Number:
04-H-0213
Summary:
This study will examine whether cytokine gene polymorphisms affect the progression or response to therapy of bone marrow failure disorders. Cytokine genes instruct cells to produce proteins called cytokines that influence immune system response. As with many genes, the cytokine genes differ slightly from person to person. These differences are called gene polymorphisms. Different patients with the same bone marrow failure disease often progress and respond to treatment differently. This study will look at the possible role of cytokine gene polymorphisms in these differences.

Patients between 2 and 80 years old who have participated in an NHLBI Hematology Branch treatment protocol for acquired aplastic anemia, myelodysplastic syndrome, or pure red cell aplasia are recruited to participate in this study. Blood collected and stored at the time of screening for the treatment protocol will be tested for cytokine gene polymorphisms. No additional tests, procedures, or treatments are involved in this study.

Sponsoring Institute:
National Heart, Lung and Blood Institute (NHLBI)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): None

Eligibility Criteria:
INCLUSION CRITERIA:

Participation on a Hematology Branch bone marrow failure treatment protocol.

Diagnosis with one of the following bone marrow failure conditions:

Acquired aplastic anemia

Myelodysplastic syndrome (MDS)

Pure red cell aplasia (PRCA)

For adults: Ability to comprehend the investigational nature of the study and provide informed consent. For minors: Written informed consent from one parent or guardian. Informed assent from minors: The process will be explained to the minor on a level of complexity appropriate for their age and ability to comprehend.

Age greater than or equal to 2 and less than or equal to 80.

EXCLUSION CRITERIA:

Subjects unable to comprehend the investigational nature of the laboratory research.

Special Instructions: Currently Not Provided
Keywords:
Aplastic Anemia
Mylodysplastic Syndrome
Pure Red Cell Aplasia
Tissue Procurement
Tumor Necrosis Factor Alpha (TNF-Alpha)
Interferon-Gamma (IFN-Gamma)
Transforming Growth Factor Beta 1 (TGF-B1)
Interleukin-10 (IL-10)
Interleukin-1 Receptor Antagonist (IL-1 Ra)
Vitamin D Receptor (VitD R)
Recruitment Keywords:
Bone Marrow Failure
Aplastic Anemia
Myelodysplastic Syndrome
MDS
Pure Red Cell Aplasia
PRCA
Conditions:
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Young NS, Maciejewski J. The pathophysiology of acquired aplastic anemia. N Engl J Med. 1997 May 8;336(19):1365-72. Review. No abstract available. PMID: 9134878

Haukim N, et al. Cytokine gene polymorphism in human disease: on-line databases, supplement 2. Genes Immun. 2002 Sep;3(6):313-30. Review. No abstract available. PMID: 12209358

Dufour C, et al. Interferon gamma and tumour necrosis factor alpha are overexpressed in bone marrow T lymphocytes from paediatric patients with aplastic anaemia. Br J Haematol. 2001Dec;115(4):1023-31. PMID: 11843845

Active Accrual, Protocols Recruiting New Patients

If you have:


Command Menu Bar

Search The Studies | Help | Questions |
Clinical Center Home | NIH Home


Clinical Center LogoWarren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/20/2004

Search The Studies Help Questions