NIH Clinical Research Studies

Protocol Number: 04-HG-0092

Active Accrual, Protocols Recruiting New Patients

Title:
Bioenergetic Function in Parkinson's Disease
Number:
04-HG-0092
Summary:
This study will examine and compare blood samples from healthy volunteers and patients with Parkinson's disease to identify abnormalities associated with Parkinson's disease. Disease symptoms include slowness of movement, hand or leg shaking, and stiffness. Some patients have difficulty with balance. Information from this study may provide information on how Parkinson's disease affects the brain and body, and may help lead to a test for earlier diagnosis.

Healthy volunteers and patients with Parkinson's disease who are 18 years of age or older may enroll in this study. Participants will undergo the following procedures:

- Physical examination, including evaluation of strength, feeling, coordination, and balance

- Blood drawing: 150 milliliters (about 10 tablespoons) of blood will be drawn

- Personal and family medical history

- Consent to access medical records for research purposes

Blood samples will be examined for:

- Genetic analysis

- Study of specific proteins and lipids

- Study of mitochondria (parts of cells that make energy)

Sponsoring Institute:
National Human Genome Research Institute (NHGRI)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): Children

Eligibility Criteria:
INCLUSION CRITERIA:

Decisionally impaired subjects will be enrolled.

EXCLUSION CRITERIA:

No person under the age of 18 will be enrolled in this study. This is due to the fact that, except for very rare occasions, Parkinson's disease affects only adults.

Special Instructions: Currently Not Provided
Keywords:
Mitochondria
Proteasome
Lipid
Polymorphism
Genetic
Recruitment Keywords:
Parkinson Disease
PD
Heredity
Parkinson Disease At Risk
Healthy Volunteer
HV
Conditions:
Parkinson Disease
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL. Related Articles, Links Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 1997 Jun 27; 276(5321): 2045-7.

PMID: 9197268

Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N. Related Articles, Links Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature. 1998 Apr 9; 392(6676): 605-8.

PMID: 9560156

Leroy E, Boyer R, Auburger G, Leube B, Ulm G, Mezey E, Harta G, Brownstein MJ, Jonnalagada S, Chernova T, Dehejia A, Lavedan C, Gasser T, Steinbach PJ, Wilkinson KD, Polymeropoulos MH. Related Articles, Links The ubiquitin pathway in Parkinson's disease. Nature. 1998 Oct 1; 395(6701): 451-2. No abstract available. PMID: 9774100

Active Accrual, Protocols Recruiting New Patients

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