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Protocol Number:
04-HG-0092
- Title:
Bioenergetic Function in Parkinson's Disease
- Number:
04-HG-0092
- Summary:
This study will examine and compare blood samples from healthy volunteers and patients with Parkinson's disease to identify abnormalities associated with Parkinson's disease. Disease symptoms include slowness of movement, hand or leg shaking, and stiffness. Some patients have difficulty with balance. Information from this study may provide information on how Parkinson's disease affects the brain and body, and may help lead to a test for earlier diagnosis.
Healthy volunteers and patients with Parkinson's disease who are 18 years of age or older may enroll in this study. Participants will undergo the following procedures:
- Physical examination, including evaluation of strength, feeling, coordination, and balance
- Blood drawing: 150 milliliters (about 10 tablespoons) of blood will be drawn
- Personal and family medical history
- Consent to access medical records for research purposes
Blood samples will be examined for:
- Genetic analysis
- Study of specific proteins and lipids
- Study of mitochondria (parts of cells that make energy)
- Sponsoring Institute:
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National Human Genome Research Institute (NHGRI)
- Recruitment Detail
- Type:
Active Accrual Of New Subjects
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
INCLUSION CRITERIA:
Decisionally impaired subjects will be enrolled.
EXCLUSION CRITERIA:
No person under the age of 18 will be enrolled in this study. This is due to the fact that, except for very rare occasions, Parkinson's disease affects only adults.
- Special Instructions:
Currently Not Provided
- Keywords:
-
Mitochondria
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Proteasome
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Lipid
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Polymorphism
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Genetic
- Recruitment Keywords:
-
Parkinson Disease
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PD
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Heredity
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Parkinson Disease At Risk
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Healthy Volunteer
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HV
- Conditions:
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Parkinson Disease
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Contacts:
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Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citations:
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Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL. Related Articles, Links Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 1997 Jun 27; 276(5321): 2045-7.
PMID: 9197268
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Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N. Related Articles, Links Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature. 1998 Apr 9; 392(6676): 605-8.
PMID: 9560156
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Leroy E, Boyer R, Auburger G, Leube B, Ulm G, Mezey E, Harta G, Brownstein MJ, Jonnalagada S, Chernova T, Dehejia A, Lavedan C, Gasser T, Steinbach PJ, Wilkinson KD, Polymeropoulos MH. Related Articles, Links The ubiquitin pathway in Parkinson's disease. Nature. 1998 Oct 1; 395(6701): 451-2. No abstract available. PMID: 9774100
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Warren Grant Magnuson Clinical Center (CC) National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/20/2004
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