Protocol Number: 04-I-0231

Title:

Procurement of Clinical Specimens for Immunologic or Genetic Studies in Inflammatory Bowel Diseases

Number:

04-I-0231

Summary:

This study will collect tissue specimens to be used for research on inflammatory bowel disease. The tissues will be used to explore why people get inflammatory bowel disease and to try to develop new treatments based on the study results. Tissue from patients with IBD will be compared with that from patients who do not have the disease

Patients who undergo bowel surgery for inflammatory bowel disease (IBD) or another bowel disorder may be eligible for this study. Patients with IBD must be at least 4 years of age; those with another disorder must be 18 years of age or older.

Participants undergo bowel surgery for their disease. Some of the intestinal tissue removed during the surgery that is not needed for medical care, such as for pathological examination, is provided to researchers for study under this protocol. In addition, patients with IBD provide a blood sample for genetic testing. Several genetic variations, or mutations, may increase the risk of developing IBD; blood samples from patients may help identify these variations.

Sponsoring Institute:

National Institute of Allergy and Infectious Diseases (NIAID)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: Yes

Population Exclusion(s): None

Eligibility Criteria:

SUBJECTS WITH INFLAMMATORY BOWEL DISEASE:

INCLUSION CRITERIA:

Presence of idiopathic inflammatory bowel disease as established by prior endoscopic, histologic, and/or radiographic findings.

Ability to give consent or have legally authorized person give consent and agree to sample storage.

EXCLUSION CRITERIA:

Less than 4 years old.

SUBJECTS WITHOUT INFLAMMATORY BOWEL DISEASE:

INCLUSION CRITERIA:

Absence of idiopathic inflammatory bowel disease as established by tests that exclude these diagnoses.

Ability to give consent and agree to sample storage.

EXCLUSION CRITERIA:

Less than 18 years of age.

Special Instructions: Currently Not Provided

Keywords:

Surgery

Intestinal Resection

Blood Sample

Recruitment Keywords:

None

Conditions:

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations: Not Provided

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/23/2004