Protocol Number: 04-N-0146

Title:

fMRI Study on Mechanism of Rhythm Perception and Generation

Number:

04-N-0146

Summary:

This study will examine how different brain areas are involved in the perception of rhythmic patterns and the performance of rhythmic movements. Patients with certain types of brain diseases, such as Parkinson's disease and some types of stroke, may have difficulty performing rhythmic movements, such as finger tapping.

Healthy, right-handed volunteers between 21 and 65 years of age may be eligible for this study. Candidates with visual, motor or hearing problems are excluded, as are musicians and pregnant women.

Participants will come to the National Institutes of Health (NIH) Clinical Center for up to six sessions of functional magnetic resonance imaging (fMRI) scanning. MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues. The scanner is a metal cylinder surrounded by a magnetic field. During the MRI, the subject lies still for up to 20 minutes at a time on a table in the cylinder and wears earplugs to muffle loud knocking noises that occur with the electrical switching of the magnetic fields. He or she can communicate with the MRI staff through a microphone at all times during the procedure.

For fMRI, images are obtained while the subject performs a task, such as hearing sounds or moving a finger. The machine detects changes in brain movement that are involved in performing the task. The tasks are explained, and subjects can practice them before entering the scanner.

Sponsoring Institute:

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria:

INCLUSION CRITERIA:

Forty healthy, right-handed adult (aged between 21 to 65 years old) volunteers will be recruited from people who are registered as HMCS normal volunteers. All subjects participating in MR studies should have a valid Clinical Center Medical Record Number.

Female subjects of childbearing potential will have a pregnancy test and a specific interview prior to the study to ensure that pregnant subjects will not participate in the study.

EXCLUSION CRITERIA:

Subjects with implanted devices such as pacemakers, medication pumps or defibrillators, metal in the cranium except mouth, intracardiac lines, history of shrapnel injury or any other condition/device that may be contraindicated or prevent the acquisition of MRI.

Pregnant female

Subjects with claustrophobia

Subjects with any visual, motor or hearing difficulties

Musicians

Special Instructions: Currently Not Provided

Keywords:

Movement

Anticipation

Stimulation

Timing

Execution

Perception

Rhythm

Recruitment Keywords:

Healthy Volunteer

HV

Conditions:

Healthy

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:

Artieda J, Pastor MA, Lacruz F, Obeso JA. Temporal discrimination is abnormal in Parkinson's disease.

Brain. 1992 Feb;115 Pt 1:199-210. PMID: 1559154

Aschersleben G. Temporal control of movements in sensorimotor synchronization. Brain Cogn. 2002 Feb;48(1):66-79. PMID: 11812033

Asanuma H, Keller A. Neuronal mechanisms of motor learning in mammals. Neuroreport. 1991 May;2(5):217-24. Review.

PMID: 1912451

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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Bethesda, Maryland 20892. Last update: 10/16/2004