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Protocol Number:
92-M-0132
- Title:
Treatment of Sydenham Chorea with Plasma Exchange or Prednisone
- Number:
92-M-0132
- Summary:
Sydenham chorea (SC) is an uncommon autoimmune neuropsychiatric disorder. It is a result of an abnormal immune reaction to a bacterial throat infection (streptococcal pharyngitis). Children with this disorder have abnormal bodily movements (chorea) and psychiatric symptoms, particularly mood swings (emotional lability), inattention, and obsessive compulsive symptoms. Although thought to be a mild self resolving disorder, children with SC can be severely disabled for many months as a result of the movements, may have multiple recurrences over the subsequent years, and can suffer from disabling cardiac, neurologic, and psychiatric symptoms for many years after the initial episode.
Presently there is no cure for Sydenham chorea. Some medical treatment exists for control of the movement symptoms.
Previous research comparing the steroid prednisone (PDN), intravenous immunoglobulin (IVIG), and plasma exchange (PEX), has shown IVIG and PEX to be superior choices for treatment of the first episode of SC. However, the results are preliminary findings and have not yet reached statistical significance. Researchers will stop testing IVIG therapy and lower the amount of patients involved in the study in order to achieve statistical significance.
This study will continue to compare the remaining 2 therapies for SC, PDN and PEX.
- Sponsoring Institute:
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National Institute of Mental Health (NIMH)
- Recruitment Detail
- Type:
Follow-up Of Previously Enrolled Subjects Only
- Gender:
Male & Female
- Referral Letter Required:
Yes
- Population Exclusion(s):
None
- Eligibility Criteria:
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Special Instructions:
Follow-up appointments required for one year after treatment
- Disease Category:
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PROTICD
- Keywords:
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Sydenham Chorea
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Cortical Stimulation
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Magnetic Stimulation
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Immunomodulatory Treatments
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Antibody Mediated Neuropsychiatric Disorders
- Recruitment Keywords:
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None
- Conditions:
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Autoimmune Disease
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Mental Disorder Diagnosed in Childhood
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Rheumatic Fever
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Streptococcal Infection
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Sydenham Chorea
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Contacts:
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This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Citations:
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Case study: A new infection-triggered, autoimmune subtype of pediatric OCD and Tourette's syndrome
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Sydenham's chorea: A model for childhood autoimmune neuropsychiatric disorders
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Rheumatic fever: the interplay between host, genetics and microbe
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Warren Grant Magnuson Clinical Center (CC) National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/22/2004
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