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Protocol Number:
94-N-0186
- Title:
Positron Emission Tomographic (PET) Scanning of Sympathetic Innervation and Function in Patients with Neurocardiologic Disorders
- Number:
94-N-0186
- Summary:
This study is designed to use PET scans in order to measure activity of the sympathetic nervous system. The sympathetic nervous system is the portion of the nervous system that maintains a normal supply of blood and fuel to organs during stressful situations.
PET scan or Positron Emission Tomography is an advanced form of an X-ray. It is used to detect radioactive substances in the body. During this study researchers plan to inject small amounts of the radioactive drug fluorodopamine into patients. Fluorodopamine is very similar to the chemicals found in the sympathetic nervous system. It can attach to sympathetic nerve endings and allow researchers to view them with the aid of a PET scan. One area of the body with many sympathetic nerve endings is the heart. After giving a dose of fluorodopamine, researchers will be able to visualize all of the sympathetic nerve endings involved in the activity of the heart. In addition, this diagnostic test will help researchers detect abnormalities of the nervous system of patient's hearts.
- Sponsoring Institute:
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National Institute of Neurological Disorders and Stroke (NINDS)
- Recruitment Detail
- Type:
Follow-up Of Previously Enrolled Subjects Only
- Gender:
Male & Female
- Referral Letter Required:
Yes
- Population Exclusion(s):
None
- Eligibility Criteria:
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Special Instructions:
This protocol is currently not recruiting Subjects.
This protocol includes positron emission tomography scanning and associated tests.
- Disease Category:
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PROTICD
- Keywords:
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Sympathetic Nervous System
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Dysautonomias
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Postural Tachycardia Syndrome
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Neurocardiogenic Syncope
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Hypernoradrenergic Hypertension
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Sympathectomy
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Fluorodopamine
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Positron Emission Tomography
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Norepinephrine
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Dopamine
- Recruitment Keywords:
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Neurocardiologic Disorder
- Conditions:
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Autonomic Nervous System Disease
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Hypertension
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Tachycardia
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Vasovagal Syncope
- Investigational Drug(s):
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Trimethaphan
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6-[18F]Fluorodopamine
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Yohimbine
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[13N]-Ammonia
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Tyramine
- Investigational Device(s):
- None
- Contacts:
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This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Citations:
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Positron emission tomographic imaging of cardiac sympathetic innervation and function
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Positron emission tomographic imaging of cardiac sympathetic innervation using 6-[18F]fluorodopamine: Initial findings in humans
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Sympathetic cardioneuropathy in dysautonomias
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Warren Grant Magnuson Clinical Center (CC) National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 08/17/2004
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