NIH Clinical Research Studies

Protocol Number: 96-M-0086

Active Followup, Protocols NOT Recruiting New Patients

Title:
Evaluation of rTMS in the Treatment of Mood Disorders
Number:
96-M-0086
Summary:
This study is designed to evaluate repetitive transcranial magnetic stimulation (rTMS) as a potential treatment for depression. In rTMS, a rapidly changing magnetic field passes through your scalp and skull and generates a small electrical pulses in your brain. rTMS at lower intensities has helped some people with depression but we do not know what the results will be in your case using higher intensities, or whether you will be randomized to 3 weeks of high frequency (20 cycles er second), low frequency (1 cycle per second), or inactive (sham)rTMS. You will be assigned to receive one of these types of rTMS over the left front art of your brain five times per week for the three weeks. Each rTMS treatment session should take between 20-30 minutes of actual stimulation, but weekly ratings, memory testing, and blood sampling may require several hours per week. We will also ask you to have brain imaging procedures to see if these will predict response to high vs. low frequency rTMS. If you are randomized to the 3 weeks of sham rTMS, you will have the opportunity to receive one of the active stimulation frequencies for an additional 3 weeks. Responders to any phase will be offered an additional month of rTMS prior to study termination and recommendations of alternative treatments.
Sponsoring Institute:
National Institute of Mental Health (NIMH)
Recruitment Detail
Type: Follow-up Of Previously Enrolled Subjects Only
Gender: Male & Female
Referral Letter Required: Yes
Population Exclusion(s): None

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
Special Instructions: Currently Not Provided
Disease Category:
PROTICD
Keywords:
Affective Disorders
Repetitive Transcranial Magnetic Stimulation
Mania
Bipolar Disorder
Depression
Unipolar Disorder
Recruitment Keywords:
Bipolar Disorder
Unipolar Depression
Conditions:
Bipolar Disorder
Mood Disorder
Unipolar Depression
Investigational Drug(s):
None
Investigational Device(s):
Magstim Super Rapid Magnetic Stimulator
Cadwell MES-10

Contacts:
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citations:
Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression

Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism

Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients

Active Followup, Protocols NOT Recruiting New Patients

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