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Protocol Number:
96-M-0086
- Title:
Evaluation of rTMS in the Treatment of Mood Disorders
- Number:
96-M-0086
- Summary:
This study is designed to evaluate repetitive transcranial magnetic stimulation (rTMS) as a potential treatment for depression. In rTMS, a rapidly changing magnetic field passes through your scalp and skull and generates a small electrical pulses in your brain. rTMS at lower intensities has helped some people with depression but we do not know what the results will be in your case using higher intensities, or whether you will be randomized to 3 weeks of high frequency (20 cycles er second), low frequency (1 cycle per second), or inactive (sham)rTMS. You will be assigned to receive one of these types of rTMS over the left front art of your brain five times per week for the three weeks. Each rTMS treatment session should take between 20-30 minutes of actual stimulation, but weekly ratings, memory testing, and blood sampling may require several hours per week. We will also ask you to have brain imaging procedures to see if these will predict response to high vs. low frequency rTMS. If you are randomized to the 3 weeks of sham rTMS, you will have the opportunity to receive one of the active stimulation frequencies for an additional 3 weeks. Responders to any phase will be offered an additional month of rTMS prior to study termination and recommendations of alternative treatments.
- Sponsoring Institute:
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National Institute of Mental Health (NIMH)
- Recruitment Detail
- Type:
Follow-up Of Previously Enrolled Subjects Only
- Gender:
Male & Female
- Referral Letter Required:
Yes
- Population Exclusion(s):
None
- Eligibility Criteria:
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Special Instructions:
Currently Not Provided
- Disease Category:
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PROTICD
- Keywords:
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Affective Disorders
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Repetitive Transcranial Magnetic Stimulation
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Mania
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Bipolar Disorder
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Depression
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Unipolar Disorder
- Recruitment Keywords:
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Bipolar Disorder
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Unipolar Depression
- Conditions:
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Bipolar Disorder
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Mood Disorder
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Unipolar Depression
- Investigational Drug(s):
- None
- Investigational Device(s):
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Magstim Super Rapid Magnetic Stimulator
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Cadwell MES-10
- Contacts:
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This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Citations:
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Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression
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Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism
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Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients
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Warren Grant Magnuson Clinical Center (CC) National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/19/2004
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