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Protocol Number:
99-H-0140
- Title:
A Clinical Trial of TNFR:Fc in a Segmental Allergen Challenge Model of Asthma
- Number:
99-H-0140
- Summary:
The proposed study is a phase II clinical trial of TNFR:Fc therapy in a segmental allergen bronchoprovocation model of atopic asthma. The goal of this study is to assess whether inhibition of tumor necrosis factor (TNF) bioactivity can attenuate airway inflammation in mild-to-moderate allergic asthmatics. This protocol will utilize a randomized, double-blind, placebo-controlled trial design. TNF bioactivity will be inhibited via systemic administration (e.g., subcutaneous injection) of a dimeric fusion protein consisting of the extracellular ligand binding domain of the 75-kilodalton TNF receptor linked to the Fc portion of human IgG1 (TNFR:Fc, Immunex). The data generated by this study will address the utility of anti-TNF therapy for patients with asthma.
- Sponsoring Institute:
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National Heart, Lung and Blood Institute (NHLBI)
- Recruitment Detail
- Type:
Follow-up Of Previously Enrolled Subjects Only
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
None
- Eligibility Criteria:
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Special Instructions:
Currently Not Provided
- Disease Category:
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PROTICD
- Keywords:
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Bronchoprovocation
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Airway Inflammation
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Tumor Necrosis Factor
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Bronchoalveolar Lavage
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Pulmonary Function Test
- Recruitment Keywords:
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Asthma
- Conditions:
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Asthma
- Investigational Drug(s):
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TNFR:Fc
- Investigational Device(s):
- None
- Contacts:
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This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Citations:
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Potentially avoidable hospitalizations: inequalities in rates between US socioeconomic groups
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A national estimate of the economic costs of asthma
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Cytokines in symptomatic asthma airways
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Warren Grant Magnuson Clinical Center (CC) National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/27/2004
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