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506U78 in Treating Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or T-cell Lymphoma
This study is no longer recruiting patients.
Sponsored by: | National Cancer Institute (NCI) M.D. Anderson Cancer Center
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Information provided by: | National Cancer Institute (NCI) |
Purpose
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of 506U78 in treating patients who have recurrent or refractory non-Hodgkin's lymphoma or T-cell lymphoma.
Condition | Treatment or Intervention | Phase |
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recurrent diffuse small lymphocytic/marginal zone lymphoma recurrent adult T-cell leukemia/lymphoma angioimmunoblastic T-cell lymphoma small intestine lymphoma Waldenstrom's Macroglobulinemia recurrent grade I follicular small cleaved cell lymphoma recurrent grade II follicular mixed cell lymphoma |
Drug: U78 |
Phase II |
MedlinePlus related topics: Blood and Blood Disorders; Cancer; Cancer Alternative Therapy; Circulatory Disorders; Digestive Diseases; Immune System and Disorders; Leukemia, Adult Acute; Leukemia, Adult Chronic; Leukemia, Childhood; Lymphatic Diseases; Lymphoma; Viral Infections
Study Type: Interventional
Study Design: Treatment
Official Title: Phase II Study of 506U78 in Patients With Recurrent or Refractory Indolent B-Cell Non-Hodgkin's Lymphoma or Peripheral T-Cell Lymphoma
Study start: April 2000
OBJECTIVES: I. Determine the response rate, failure free survival, and progression free survival of patients with recurrent or refractory indolent B-cell non-Hodgkin's lymphoma or peripheral T-cell lymphoma when treated with 506U78. II. Assess the pharmacokinetics and toxicity of this treatment in these patients.
PROTOCOL OUTLINE: Patients receive 506U78 IV over 120 minutes on days 1, 3, and 5. Treatment continues every 28 days for a maximum of 6 courses in the absence of disease progression or unacceptable toxicity. Patients are followed every 3 months.
PROJECTED ACCRUAL: A total of 51-111 patients will be accrued for this study.
Eligibility
Ages Eligible for Study: 16 Years and above
Criteria
PROTOCOL ENTRY CRITERIA:
--Disease Characteristics--
--Prior/Concurrent Therapy--
--Patient Characteristics--
Location Information
More Information
Clinical trial summary from the National Cancer Institute's PDQ® database
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