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The National
Primate Research Center (NPRC) facilities and resources
enable RPRC staff scientists and investigators from the
host institution and others across the country to
collaborate on their research projects. The centers'
specialized resources are intended to support investigators
who receive their primary research project funding from
NIH, but they also may be used by investigators who are
funded by other federal, state, and local agencies, as well
as by research foundations and the private sector. Together
the RPRCs have more than 20,000 animals representing more
than 30 species of nonhuman primates, mostly macaques.
Each RPRC has a Visiting Scientist Program that offers
advanced training and research in nonhuman primate biology.
Collaborative arrangements between investigators and center
scientific staff are encouraged and can be developed on
studies related to major human diseases, subject to the
availability of resources and center staff time. Nonhuman
primate blood samples, organs, and biological fluids are
available through the RPRCs. The following standardized
criteria and procedures have been implemented at each RPRC
to facilitate utilization of center resources:
- The nature and scope of the proposed research must be
best conducted with nonhuman primates and be compatible
with available center resources.
- The proposed research must have high scientific merit as
determined by peer review.
- NIH–funded research takes precedence over research
activities funded by other sources.
- Grants must contain appropriate budgets for the RPRC
portion, including animal per diem costs, RPRC service
charges, and related items. Sharing of animals during
experimentation and returning the animals to the colony for
future experimental use are contributing factors to the
overall costs.
- Availability of RPRC resources, including animals, space,
research services and support, and special requirements,
such as biosafety facilities, are also limiting factors
that must be considered by the investigator.
- Because of potential contamination (e.g., viral,
microbial), movement of animals into or out of the RPRC
facilities is not allowed. Thus, the proposed research
using live animals must use RPRC animals, and the research
must be conducted at the RPRC.
- An initial research proposal must be submitted by the
researcher to the RPRC prior to submitting an application
for funding. The director then consults with the research
services, veterinary, and colony management staff members
at the center to assess resource availability and project
feasibility. (Note that special requests or conditions
regarding animals of certain age, gender, weight, or other
stipulations affect the RPRC's capability to meet the
researcher's needs.)
- When resource availability and project feasibility have
been established, the RPRC staff will provide budget
information to the researcher regarding the center costs to
be included in the formal research proposal.
- The scientific merit of the proposal must then be
evaluated through the NIH peer review process or through a
similar process at other agencies. However, small pilot
projects with other funding sources may be considered. In
the latter case, the peer review is conducted by the RPRC
Research Advisory Committee.
- In addition to the scientific peer review, a protocol
approved by the institutional animal care and use
committees (IACUC) at both the investigator's institution
and the RPRC must be in place. Protocols must also be
established to address biosafety concerns. (Note that these
issues can be addressed simultaneously with the scientific
evaluation but are frequently raised during the peer review
process.)
- When the investigator has received notification of
funding, the RPRC director should be advised immediately so
that the resources at the center may be reserved for the
funded proposal.
- Biological materials such as blood samples, organ
tissues, and biological fluids can be obtained by
contacting the directors and staff of the RPRCs.
All publications resulting from research conducted at or with
RPRC resources must bear an appropriate acknowledgment of
center support.
For additional information about the Visiting Scientist
Program and resources available at a specific center,
including applying to utilize a center's resources, contact
the center director or appropriate contact person listed in
this directory.
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University of California, Davis
Davis, CA 95616
URL: www.crprc.ucdavis.edu
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Center Director and Contact
Dallas M. Hyde, Ph.D.
530-752-0420; Fax: 530-752-2880
E-mail: dmhyde@ucdavis.edu
Additional Contact
Jenny Short
530-752-7169
Principal Investigator
Barry M. Klein, Ph.D.
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The center is located on a 300-acre tract 3 miles from the main campus of the University of California, Davis. The university administers the center and provides its academic setting.
The California National Primate Research Center is an
organized research unit of the University of California,
Davis. Its mission is to provide interdisciplinary programs
in biomedical research on significant human health-related
problems in which nonhuman primates are the models of
choice.
The center has a diverse program of research utilizing the
nonhuman primate. Research projects encompass many aspects
of biology and medicine, including AIDS and other
infectious diseases; reproductive issues such as those
associated with conception, contraception, early pregnancy,
and fetal growth and development; neurodegenerative
conditions such as Alzheimer's disease; nutritional
deficiencies; pulmonary disorders such as asthma;
xenotransplantation; drug addiction and behavior-related
drug addiction; acute and chronic stress; biobehavioral
organization; social relationships, brain and behavior;
neurobiology, cognitive function, and behavioral
development.
Research units at the CRPRC include brain, mind, and
behavior; reproductive and genetic sciences; respiratory
diseases, and virology and immunology. There is also an
affiliate research program, core services, primate
services, and medicine division. Research opportunities are
available for investigators from national and international
institutions, as well as scientists within the UC Davis
research community.
To Outside Investigators
Specimens
Organs and tissues are provided when available; other
biological samples are provided on special request.
Shipping, collecting, and processing costs are charged to
the requestor.
To Collaborating Scientists
Scientists wishing to conduct research at the center must
have their projects reviewed and approved by the center
director, scientific advisory committee, and campus animal
care review committee. The center's services are available
to collaborating scientists on a fee-for-service basis.
Services include:
Core Science
Allergy Core - Laurel Gershwin, D.V.M., Ph.D.
Endocrine Core - William Lasley, Ph.D., Sally Mendoza,
Ph.D.
Genetics Core - Leslie Lyons, Ph.D.
Immunology Service Core - Mike McChesney, Ph.D. Christopher
Miller, D.V.M., Ph.D.
Inhalation Exposure Facility - Charles Plopper, Ph.D.
Morphology Core - Kent Pinkerton, Ph.D.
Simian Retrovirus Laboratory - Nicholas Lerche, D.V.M.,
M.P.V.M.
Contact Core Directors at 530-752-0447.
Primate Medicine
Preventive medicine and epidemiologic evaluation, surgery,
radiology, therapeutics, specialized medical procedures.
Diagnostic Pathology and Clinical Laboratory
Services
Bacteriology, biochemistry, hematology, immunology,
parasitology, pathology, virology.
Animals
Center breeding colony: cynomolgus macaque (Macaca
fascicularis), rhesus macaque (M. mulatta).
Center research colony: Callicebus moloch, M. mulatta,
M. fascicularis.
Index Terms
AIDS, asthma, birth defects, genetics, immunology,
inhalation toxicology, neuroscience, primate behavior,
primates, virology.
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One Pine Hill Drive
P. O. Box 9102
Southborough, MA 01772-9102
URL: www.hms.harvard.edu/nerprc/
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Center
Director and Contact
Ronald C. Desrosiers, Ph.D.
508-624-8002; Fax: 508-460-0612
E-mail: ronald_desrosiers@hms.harvard.edu
Additional Contact
James T. Wortham, M.P.A.
508-624-8003
E-mail: james_wortham@hms.harvard.edu
Principal Investigator
Joseph B. Martin, M.D., Ph.D.
Dean, Harvard Medical School
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The center is
located on 135 acres in Southborough, Massachusetts, about
30 miles from Boston. Harvard Medical School administers
the center and provides its academic setting.
HIV/SIV/AIDS, oncogenic herpesviruses, other infectious
diseases, behavioral biology, neurodegenerative diseases,
neurochemistry, brain imaging, and neuropharmacology.
Use of simian immunodeficiency virus (SIV) as a model for
AIDS in rhesus monkeys, host and viral determinants of AIDS
pathogenesis, strategies for vaccine development,
immune-based therapeutic strategies, pathogenesis of
opportunistic infections.
Elucidation of spontaneous diseases of nonhuman primates
and development of new models for comparable human
diseases.
Neurobiology and behavioral pharmacology of cocaine abuse
with emphasis on mechanisms of action, behavioral effects,
and treatment. Use of
1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) model
for Parkinson's disease, to develop imaging agents for
chronic neurologic disorders, to monitor disease
progression and effectiveness of therapeutic strategies.
Drug discovery and development for central nervous system
disorders.
To Outside Investigators
Specimens
Tissue specimens, organs, blood, skeletal structures, viral
specimens, etc. Animals for approved research projects are
provided from breeding colonies or other sources as
required. Costs are normally assumed by the individual
requesting the specimens. To Collaborating Scientists
Scientists wishing to conduct research at the center must
have projects reviewed and approved by the center's animal
allocation committee. A brochure explaining the
collaborative research program is available from the
center. Most services are provided on a fee for service
basis. They include veterinary services, animals and animal
care, surgical and radiographic services, timed mating,
biocontainment, pathology services, and professional and
technical expertise. Animals
Colonies of rhesus macaque (Macaca mulatta),
cynomolgus macaque (M. fascicularis), common
marmoset (Callithrix jacchus), and squirrel monkey
(Saimiri sciureus). Other species can be obtained.
Animals with exceptional characteristics
(specific-pathogen-free, timed pregnancy, surgically
altered, etc.) can be made available if needed. Index
Terms
AIDS, cardiovascular physiology, cocaine abuse, cognitive
deficits, imaging agents, myocardial diseases,
neurodegen-erative diseases, neuropsychiatric drugs,
Parkinson's disease, viral diseases.
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505 N.W. 185th Avenue
Beaverton, OR 97006
URL: www.ohsu.edu/orprc
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Center
Director and Contact
M. Susan Smith, Ph.D.
503-690-5300; Fax: 503-690-5569
E-mail: smithsu@ohsu.edu
Additional Contact
P. Michael Conn, Ph.D.
503-690-5297; Fax: 503-690-5569
E-mail: connm@ohsu.edu
Principal Investigator
Daniel M. Dorsa, Ph.D.
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The center is
located on the 247-acre OHSU West campus 12 miles from
downtown Portland. Oregon Health Sciences University
administers the center and provides its academic
setting.
Reproductive sciences, neuroscience, pathobiology, and
immunology.
Control of folliculogenesis and the corpus luteum, factors
that control sperm motility and maturation,
neuroendocrinology, hormonal control of parturition,
steroid receptors in primate reproductive tract and brain
tissues, implantation, in vitro fertilization, hormonal
control of peptide and catecholamine gene expressions.
Neurological processes in regeneration of neural tissue,
interactions between neural and immune systems, factors
controlling differentiation and growth of neurons and glia,
degenerative diseases, developmental neurobiology, and
control of reproduction and of food intake.
Pathobiology and immunology, therapeutic modification of
atherosclerosis, human and animal models related to
retrovirus infections.
To Outside Investigators
Tissue specimens, organs, etc., when available. Costs are
normally assumed by the requestor. To Collaborating
Scientists
Scientists wishing to conduct research must have their
projects approved by the institutional animal care and use
committee and the research advisory subcommittee. Most
services are provided on a fee for service basis. They
include: Medical Services
Physiological data, surgery, ultrasound, DEXA scanning.
Colony Operations
Primates, guinea pigs, mice, hamsters, rats, rabbits.
Pathology
Necropsies, tissue distribution, consultation.
Microscopy and Image Analysis Services
Confocal and electron microscopy. Data
Processing
Comprehensive animal information system, consultation and
support on statistical processing, extensive
radioimmunoassay support. Library
8,300 books, 15,250 bound journals, 200 journal
subscriptions, MEDLARS searching services, PriMed database,
Internet. Endocrine Services Laboratory
Steroid and pituitary protein hormone radioimmunoassays.
Medical Illustrations and Photography
Animals
Japanese macaque (Macaca fuscata), rhesus macaque
(M. mulatta), pigtailed macaque (M.
nemestrina); Includes an outdoor troop of about 190 M.
fuscata and a colony of 2,800 M. mulatta.
Molecular Biology Core
DNA synthesis and sequencing, cDNA probes. Cell
Culture Core
Maintenance of cell lines, media preparation.
Morphology Core
Tissue embedding and sectioning, immunohistochemistry, in
situ hybridization. Assisted Reproductive
Technologies Core
Procedures related to in vitro fertilization, nuclear
transfer, intracytoplasmic sperm injection, culture media,
gamete preservation.
Index Terms
AIDS, confocal microscopy services, molecular biology,
neuroscience, nonhuman primate resources, reproductive
biology.
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Southwest Foundation for Biomedical Research
Post Office Box 760549
San Antonio, TX 78245-0549
URL: www.snprc.org
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Center
Director
John L. VandeBerg, Ph.D.
Center Associate Director and Contact
Suzette D. Tardif, Ph.D.
210-258-9885; Fax: 210-258-9883
E-mail: stardif@sfbr.org
Additional Contact
Thomas M. Butler, D.V.M.
210-258-9465; Fax: 210-670-3305
E-mail: tbutler@sfbr.org
Principal Investigator
Frank F. Ledford Jr., M.D.
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The center is
located on the 397-acre campus of the Southwest Foundation
for Biomedical Research, approximately 12 miles from
downtown San Antonio and 7 miles from the University of
Texas Health Science Center at San Antonio. The Southwest
Foundation administers the center.
Nonhuman primate models of human diseases, including common
chronic diseases and infectious diseases; genetic and
environmental effects on physiological processes and on
susceptibility to specific diseases.
Genetics
Genetic and environmental bases for susceptibility to
atherosclerosis, hypertension, osteoporosis, obesity, and
infectious diseases; construction of baboon and rhesus gene
maps; genomic screening for disease-related genes; genetic
management strategies for research colonies; development of
new genetic analytic strategies and software.
Infectious Diseases
AIDS; hepatitis B, C, and E; herpes B and other
herpesviruses; Chagas disease; emerging viral diseases;
fundamental research and vaccine and drug testing.
Neonatal Diseases
Bronchopulmonary dysplasia and chronic lung disease of
infancy. Physiology
Control of ingestive behavior, dietary effects on blood
pressure, brain imaging, lipid metabolism, gene therapy.
Pathobiology
Spontaneous diseases and experimental models of diseases.
Behavior
Impact of enrichment strategies on behavior and well-being,
genetic and endocrine effects on maternal behavior.
To Outside Investigators
The SRPRC encourages the use of its resources by
investigators from the national and international
biomedical research communities as well as collaborative
research initiatives involving center staff and outside
investigators. In general, expenses are assumed by the
initiating investigator and collaborative research efforts
are covered by grants acquired collaboratively.
Specimens
Banked serum, tissue, and DNA samples; fresh blood, serum,
plasma, tissues, and organs. Animals
Baboon (Papio) species, chimpanzees (Pan
troglodytes), rhesus macaques (Macaca mulatta),
miscellaneous primate species, as required for specific
research purposes. Veterinary Technical Services
Timed pregnancies, tether, radiography, sonography,
endoscopy, experimental surgery, experimental diets,
nursery, behavioral assessment. Pathology
Necropsies, clinical chemistry, hematology, histology,
bacteriology, virology, parasitology. Data
Services
Colony database system, genetic analysis software, genetic
typing services.
Index Terms
AIDS, common diseases, genetic analysis, genetics,
infectious diseases, neonatal diseases, primate behavior,
primate models, vaccines, virology.
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18703 Three Rivers Road
Covington, LA 70433
URL: www2.tulane.edu/hsc/primate_facilities.cfm
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Center
Director and Contact
Andrew A. Lackner, Ph.D.
985-892-2040 x 6201; Fax: 985-893-1352
E-mail: info@tpc.tulane.edu
Additional Contact
Mike W. Aertker, M.S.E.
E-mail: aertker@tpc.tulane.edu
Principal Investigator
Paul K. Whelton, M.D., M.Sc.
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The center is
located on 500 acres near Covington, Louisiana, 35 miles
from the main Tulane University campus in New Orleans.
Tulane University administers the center and provides its
academic setting.
Infectious diseases, AIDS, Lyme disease, microsporidiosis, malaria, and gene therapy.
Microbiology
Emphasis on AIDS models, immunopathogenesis, microsporidial infections, respiratory syncitial virus, STLV/HTLV, mycobacterial diseases, simian varicella virus, and retrovirology.
Bacteriology and Parasitology
Spirochetal biology, disease pathogenesis, chemotherapy, and diagnosis of Lyme borreliosis, and animal model development, chemotherapy, and pathogenesis of Malaria.
Gene Therapy
In utero gene transfer strategy, mesenchymal stem cells and the macaque model of Krabbes disease (Globoid cell leukodystrophy).
Confocal microscopy, image-analysis, flow cytometry analysis and cell sorting, ultrasound, endoscopy, immunohistochemistry, in situ hybridization, clinical and anatomic pathology
Specimens
Tissue specimens, organs, etc., are provided when
available. Costs are normally assumed by the requestor.
Scientists who want to conduct research at the center must have their projects reviewed and approved by the Instituitional Animal Care and Use Committee. Please contact Division of Collaborative Research at
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University of Washington
I-421 Health Sciences
Box 357330
Seattle, WA 98195-7330
URL: http://wanprc.org/WaNPRC/
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Center
Director and Contact
William R. Morton, V.M.D.
206-543-1430; Fax: 206-685-0305
E-mail: pattir@bart.rprc.washington.edu
Tissue Distribution
206-221-6534
E-mail: peggys@bart.rprc.washington.edu
Principal Investigator
Sidney D. Nelson, Ph.D.
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The center is
located in the Warren G. Magnuson Health Sciences Center of
the University of Washington and at the Western Facility
Annex in Seattle.
The WaRPRC is committed to facilitation of nonhuman
primate-related research through collaborative efforts of
core and affiliate scientists. Current biomedical research
projects emphasize neurological sciences, animal models,
AIDS, virology, immunogenetics, cardiovascular function,
developmental biology, and endocrinology and metabolism.
Core Staff
Primate neuroscience, neural control of limb movement,
vestibular and oculomotor interactions, neural mechanisms
of vision, molecular structure of neuronal membranes,
animal model development, virology, viral pathogenesis,
vaccine development, therapeutic evaluation, genetic
regulation of B-cell function, primate major
histocompatibility complex, viral translation,
intracellular signaling, transplantation, gene therapy, and
immunology. Affiliated Staff
Neurological Sciences
Structure and development of monkey visual cortex, auditory
physiology, retinal development, basal ganglia function.
Animal Models
AIDS model systems, enteric pathogens, antiviral drugs,
reproductive health, venereal disease, chlamydia,
chancroid, fetal alcohol syndrome, parkinsonism,
experimental allergic encephalomyelitis, systemic
candidiasis.
Cardiovascular Disease and Function
Arterial smooth muscle cells in atherosclerosis, evaluating
blood compatibility of biomaterials, fetal hemoglobin
synthesis. Developmental Biology
Hyaline membrane disease, respiratory distress syndrome,
visual development, effect of epileptic drugs on
development, cognitive development. Endocrinology
and Metabolism Research
Reproductive physiology, regulation of glucagon, role of
somatostatin in physiology and control of somatostatin
secretion, methanol effects, methylmercury effects,
parenteral nutrition, bone loss and gain, diabetes
endocrine research. Transplantation and Prosthesis
Development
Bone marrow transplantation, lung transplantation,
neurotransplantation, cochlear prosthetics, arterial graft
development, stem cell transplantation, pancreatic
transplantation.
Affiliate Scientists/Outside Investigators
The WaRPRC is committed to providing complete access to
center resources for the research community to facilitate
all aspects of nonhuman primate-related research. The
WaRPRC provides substantial assistance for collaborative
research projects based at the center, including scientific
and technical assistance with protocol development, grant
submission, data collection and interpretation and
manuscript preparation. A computer database of more than
80,000 bibliographic records (1985 to present) of
scientific literature on nonhuman primates is available for
lease on PC-compatible computer systems. This database
includes full citation and indexing information.
Primate Information Center
Develops indexes of comprehensive, worldwide bibliographic
information regarding biomedical research on nonhuman
primates. Provides published and custom bibliographies.
Primate Supply Information Clearinghouse
Provides communication links–by telephone and through
semimonthly publication of the New Listings
Bulletin–between U.S. scientists in need of
primates or tissues and institutions that can meet their
needs. A registry of primate colonies and special services
is being developed. Tissue Distribution Program
The TDP provides samples of blood and all major tissues,
either fresh, fixed, or frozen for shipment to
investigators throughout the United States.
Pathology
The Combined Pathology Unit provides complete pathology
services including gross necropsy, biopsy, histologic
evaluation, special diagnostic staining and
immunohistochemical and in situ hybridization studies.
Scientific Illustration and Editing
Neurohistology
Immunologic Typing
Primate Colony Division
Primate health care, surgical procedures, x-ray facilities,
clinical laboratory, round-the-clock nursery care,
computerized genealogic and clinical records, psychological
well-being, preventive medicine. Biostructure
Technology Laboratory
Bioengineering
Instrumentation development, computer programming.
Animals
Cynomolgus macaque (Macaca fascicularis), rhesus
monkey (M. mulatta), pigtailed macaque (M.
nemestrina), yellow baboon (Papio cynocephalus).
Collections
A broad variety of collections are archived encompassing
developmental and physiologic data for the nonhuman
primate. Index Terms
AIDS, animal models, auditory physiology, cardiovascular
function, fetal alcohol syndrome, neurology, prosthesis
development, psychology, transplantation, vision.
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1220 Capitol Court
Madison, WI 53715-1299
URL: www.primate.wisc.edu
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Center
Director and Contact
Joseph W. Kemnitz, Ph.D.
608-263-3500; Fax: 608-263-4031
E-mail: kemnitz@primate.wisc.edu
Additional Contact
Lawrence Jacobsen
608-263-3512
E-mail: jacobsen@primate.wisc.edu;
refdesk@primate.wisc.edu;
or write the WRPRC Library
Principal Investigator
Martin T. Cadwallader, Ph.D.
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The center has
56,153 square feet of laboratory, animal, office, and
related support space within the three main buildings on
the University of Wisconsin-Madison campus. An addition of
approximately 18,500 square feet of usable space is being
built, which consists of animal housing, surgical suites,
necropsy and clinical pathology services, along with other
related support space. The university administers the
center and provides its academic setting.
Fundamental research in primate biology related to human
and animal health. There are more than 200 core and
affiliate doctoral-level staff.
There are three areas of major emphasis and a diverse
affiliate program. Reproduction and Development
Stem cell biology, embryonic differentiation and fetal
development, reproductive neuroendocrinology,
endometriosis. Aging and Metabolic Diseases
Effects of food restriction on aging, obesity and appetite
control, diabetes mellitus, polycystic ovary syndrome,
menopause, pathobiology of aging. Immunogenetics and
Virology
Simian immunodeficiency virus, molecular MHC analysis and
MHC-defined animals, cytotoxic T cells, viral transmission,
pathogenesis, and escape.
To Outside Investigators
Tissue specimens, organs, and other biological materials.
Costs are normally assumed by the requestor.
Library
Offers Internet services to the biomedical research
community through Primate Info Net (PIN), a Web site with
1600 links. PIN provides access to PrimateLit,
Primate-Science, the International Directory of
Primatology, AskPrimate, the World Directory of
Primatologists, the Audiovisual Archive, Careers in
Primatology and Primate-Jobs (see Information Services
section for URLs). Promotes document delivery, collection
development and resource sharing among the RPRCs. Works
cooperatively with the International Primatological
Society, the American Society of Primatologists, the
Primate Society of Great Britain and other organizations to
encourage communications and resource sharing. Collects
extensively in the area of primatology, including journals,
newsletters, audiovisual materials, reprints, rare books,
K–12 nonfiction, and other related items. Houses 7,500
books, 13,000 journal volumes, 300 subscriptions, 25,000
reprints, 8,000 slides and 900 videotapes.
To
Collaborating Scientists
The center actively encourages researchers from the Midwest
region and elsewhere nationally and internationally to use
its facilities and services and to conduct collaborative
studies. Scientists wishing to conduct research must have
their projects reviewed and approved by the center director
and advisory committees and have independent funding to
cover costs. Most of the center's services are available on
a fee for service basis. They include:
Research Services
Clinical laboratory tests; assay procedures for adrenal,
gonadal, and pituitary hormones; surgery; breeding colony;
reproduction technologies; and molecular procedures,
including polymerase chain reaction assays and in situ
hybridization.
Pathology Services
Diagnose clinical disease through necropsy and surgical
pathology services; assist investigators to evaluate tissue
changes in experimental disease; identify, describe, and
publish new diseases or new aspects of diseases to improve
the health of nonhuman primate populations and to establish
new models of human disease; maintain a SNOMED database of
necropsy diagnoses to aid in epidemiological studies of
primate disease; provide routine histology services to
investigators, perform in situ hybridizations on tissue
culture cells, whole mount embryos, and tissue sections for
investigators; perform digital image acquisition and
analysis for investigators.
Colony Management
Maintenance, veterinary medicine, assistance in drug
administration, specimen collection, animal handling, and
environmental enrichment.
Computer Services
Unix database, Web, and E-mail servers to support
researchers and service units. Daily operations support of
the switched ethernet-based local area network, 200+
Macintosh computer workstations, and several Intel-based
workstations used to collect and analyze data from various
instruments. Digital imaging and graphics support for
investigators.
Animals
Rhesus macaque (Macaca mulatta; about 1,080); common
marmoset (Callithrix jacchus; 300). The center
maintains a breeding colony that produces more than 80
rhesus infants a year.
Index Terms
Aging, AIDS, behavior, development, embryology,
endocrinology, genetics, immunology, neurobiology,
nutrition, virology, women's health.
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Emory University
Atlanta, GA 30322
URL: www.emory.edu/WHSC/YERKES/
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Center
Director and Contact
Stuart Zola, Ph.D.
404-727-7707; Fax: 404-727-0623
E-mail: szola@rmy.emory.edu
Principal Investigator
Michael M. E. Johns, M.D.
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Center
facilities include the Main Station on 25 acres of the
Emory University campus in Atlanta and the 117-acre Field
Station for psychobiology research in nearby
Lawrenceville.
Biomedical and biobehavioral research to improve the health
and well-being of human and nonhuman primates.
Microbiology and Immunology
Primate models for research on AIDS pathogenesis,
treatment, and vaccines; as well as other infectious
diseases including Malaria. Neuroscience
Molecular, cellular, and behavioral studies of drugs of
abuse, especially cocaine; cognitive neuroscience and brain
function. Psychobiology
Endocrine and behavioral studies of primates living in
complex social groups. Visual Science
Developmental studies of visual function.
To Outside Investigators
Research proposals by investigators from other institutions
are encouraged. Proposals should be submitted for review by
the research advisory committee to ensure that resources
are available. All proposals are reviewed by the
institutional animal care and use committee. Services
available to outside investigators at approved rates
include veterinary medicine, pathology, and biomedical
engineering.
Animals
Rhesus macaque (Macaca mulatta), pigtailed macaque
(M. nemestrina), cynomolgus macaque (M.
fascicularis), sooty mangabey (Cercocebus atys),
baboon (Papio) species, squirrel monkey (Saimiri
sciureus), chimpanzees (Pan troglodytes), tufted
brown capuchins (Cebus apella).
Service Cores
DNA microarray, molecular pathology, virology, and RIA.
Index Terms
AIDS vaccine, chimpanzee, cocaine medication, cognitive
neuroscience, interventional cardiology, malaria, rhesus
macaque, social behavior, visual development.
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University of Oklahoma Health Sciences Center
Division of Animal Resources
940 S. L. Young Boulevard, BMSB 203
Oklahoma City, OK 73190
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Principal
Investigator and Contact
Gary L. White, D.V.M.
405-271-5185; Fax: 405-271-2660
E-mail: gary-white@ouhsc.edu
Additional Contact
Richard W. Eberle
405-744-8169
E-mail: reberle@okstate.edu
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To carry out multidisciplinary studies on captive baboons
and to provide a resource of laboratory-born and
laboratory-reared animals for NIH-sponsored research
programs.
This baboon resource program will strengthen and expand
nonhuman primate biomedical and behavioral research at the
University of Oklahoma Health Sciences Center (OUHSC),
stimulate increased cooperation among regional research
institutions, and establish the OUHSC as a nationally
recognized provider of baboons as research subjects.
Current research activities involve the characterization of
the endogenous microorganisms of the conventional research
baboon, improved methods for production of baboons in a
captive environment, methods to improve the environment and
its effects on production and behavior, genetic diversity
among the baboon breeding population, and data collection
for the future development of a specific-pathogen-free
baboon breeding colony.
To Outside Investigators
Tissues and body fluids are sometimes available. Such
specimens are provided on a priority basis to NIH-
sponsored research studies. Costs of packaging and shipping
are negotiated on an individual basis to be determined by
the nature of the request.
To Collaborating Scientists
Individuals interested in collaborative studies must
provide a protocol to the principal investigator. Approval
of collaborative projects depends on the relevance of the
proposed project to the objectives of the ongoing research
effort. Complete animal husbandry, medical care, and
pathology services are available to investigators who have
approval from the principal investigator to use resource
colony animals.
Animals
Some adults and offspring will be available.
Index Terms
Baboon, behavior, breeding resource, immunology,
maternal-fetal medicine, models of infectious diseases,
Papio species, virology.
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University of Puerto Rico Medical Sciences Campus
P. O. Box 1053
Sabana Seca, PR 00952-1053
URL: http://cprc.rcm.upr.edu
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Principal
Investigator and Contact
Edmundo N. Kraiselburd, Ph.D.
787-764-4325; Fax: 787-764-4325
E-mail: ekraiselburd@rcm.upr.edu
Mailing Address
Unit of Comparative Medicine
Office B-315
University of Puerto Rico School of Medicine
Medical Sciences Campus
P. O. Box 365067
San Juan, PR 00936-5067
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Short- and long-term studies of social and sexual behavior,
population genetics, demography, reproductive biology,
psychopharmacology, functional morphological and
spontaneous diseases (arthritis, osteoporosis, adult-onset
macular degeneration, glaucoma, diabetes, obesity,
hypertension), and parasitoses of rhesus monkeys maintained
under seminatural conditions. Colony size: 900.
Sabana Seca
CPRC headquarters, SPF rhesus breeding colony and
biomedical research on spontaneous diseases (see above),
reproductive biology and embryology, social behavior,
endocrinology, medical genetics, vaccine development, and
husbandry of Cayo Santiago-derived rhesus macaques
maintained under a variety of housing configurations
(individual cages, pens, and large corrals). Colony size: 800.
CPRC Museum
Anthropological and biomedical osteological research on
2,500 complete skeletons from 10 species of nonhuman
primates, including more than 1,000 from Cayo Santiago
rhesus monkeys of known identity, age, sex, matriline, and
parity, and 175 skeletons from patas monkeys.
Virology Laboratories
Research on simian immunodeficiency virus (SIV; as a model
for AIDS in rhesus monkeys), and in strategies for the
development of vaccines against SIV and dengue viruses.
To Collaborating Scientists
CPRC welcomes collaborative research with established
behavioral and biomedical investigators and encourages the
use of its animal and osteological resources for
dissertation research. Investigators are charged modest use
fees for access to the animals, skeletal collection,
computerized database, and office space. All proposals must
receive rigorous peer review and are judged on scientific
merit, feasibility, and potential overlap with ongoing
studies. Protocols using live monkeys must be approved by
the institutional animal care and use committee (IACUC) of
the home institution, as well as the University of Puerto
Rico Medical Sciences Campus IACUC.
Index Terms
Aging, behavior, Caribbean, Cayo Santiago, diseases,
embryology, osteology, primatology, Puerto Rico, rhesus
macaque, SPF primates, vaccines.
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Primate Research Laboratory
College of Medicine
University of South Alabama
Mobile, AL 36688
URL: www.smbrr.org
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Principal
Investigator and Contact
Christian R. Abee, D.V.M.
251-460-6239; Fax: 251-460-7783
E-mail: cabee@usouthal.edu
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To carry out multidisciplinary studies of reproduction in
captive Bolivian squirrel monkeys and to provide a resource
of laboratory-born and laboratory-reared animals for
NIH-sponsored research programs.
Characterizing factors that influence captive reproduction
with emphasis on developing methods to improve reproductive
potential. A multidisciplinary approach with behavioral
studies, reproductive endocrinology, medical primatology,
and genetics is ongoing.
To Outside Investigators
Tissues and body fluids are available. Such specimens are
provided on a priority basis to NIH-sponsored research
studies that are related to the objectives of this project.
Costs of packaging and shipping are negotiated on an
individual basis to be determined by the nature of the
collaboration.
To Collaborating Scientists
Individuals interested in collaborative studies must
provide a protocol to the principal investigator. Approval
of collaborative projects depends on the relevance of the
proposed project to the objectives of the ongoing
research effort. Complete animal husbandry, medical care,
and pathology services are available without charge to
investigators who have received approval from the principal
investigator to use resource colony animals.
Animals
The breeding colony currently contains approximately 450
Bolivian squirrel monkeys of varying ages. Some offspring
and reproductive culls are available.
Core Staff
Investigators conducting studies of medical primatology,
reproductive endocrinology, data management, primate
management and husbandry, primate behavioral psychology,
and genetics.
Guest Investigators and Graduate Students
Guest investigators and graduate students interested in
studies of factors influencing reproduction of squirrel
monkeys in captivity are invited to send letters of
interest. These letters will be considered based on the
relevance of the applicant's interests to the ongoing
research effort and the availability of resources to meet
the needs of the guest investigator.
Index Terms
Breeding resource, Saimiri, squirrel monkey.
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Holloman Air Force Base
Alamogordo, NM 88330
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Contact
Ray O'Neill, Ph.D.
301-435-0744; Fax: 301-480-3819
E-mail: raymondo@ncrr.nih.gov
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The Alamogordo Primate Facility (APF) houses chimpanzees
that have been used in biomedical research, but no active, invasive
research is conducted on the site.
The APF provides for the long-term care and husbandry of
chimpanzees that have been used in biomedical research.
Charles River Laboratories Inc. operates the facility under
contract with the National Institutes of Health. To be used
in continuing virological research, the animals must be transferred to
active chimpanzee research settings.
Animals
All chimpanzees at the APF have been exposed to various
microorganisms, such as hepatitis C virus and HIV. For this
reason, they may be candidates for studies related to their
diseases, such as research protocols for HCV, HIV, etc. The
National Center for Research Resources (NCRR) may remove
infected animals from the APF to other accredited
chimpanzee facilities for research purposes. Investigators
interested in the chimpanzees at the APF should contact Dr.
Ray O'Neill in NCRR's Division of Comparative Medicine to
discuss research requirements. Dr. O'Neill can be reached
at 301-435-0744.
Index Terms
Animal husbandry.
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Yerkes National Primate Research Center
Emory University
954 North Gatewood Road NE
Atlanta, GA 30329
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Principal Investigator and Contact
Mollie A. Bloomsmith, Ph.D.
404-624-5990; Fax: 404-627-7514
E-mail: mbloomsmith@zooatlanta.org
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This behavioral research program is designed to improve the care and management of captive chimpanzees. Studies identify factors that influence the production of successful breeders from captive-born animals, identify improvements in the care and behavioral management of chimpanzees, and objectively evaluate forms of environmental enrichment and animal training.
To Collaborating Scientists and Graduate Students
Individuals interested in collaborative studies must provide a protocol for approval by the principal investigator and the appropriate institutional animal care and use committees.
Index Terms
Animal training, chimpanzee behavior, environmental enrichment, psychological well-being.
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P. O. Box 20027
Mesa, AZ 85277-0027
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Principal
Investigator and Contact of the subcontract
Jo Fritz 480-832-3780; Fax: 480-830-7039
E-mail: jopfa@qwest.net
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To ensure that behaviorally normal and physically healthy
chimpanzees (Pan troglodytes) are available for
biomedical research and future breeding. To conduct
behavioral and environmental enrichment research with a
goal of improving captive management of chimpanzees.
This resource is supported by way of a subcontract to
a cooperative agreement, which was awarded to the
University of Texas.
Development and maintenance of social behaviors,
environmental enrichment, colony management including birth
control methods.
The colony is available for research activities that do not
interfere with the primary mission of this program. All
research conducted at this facility must have prior
approval of the chief veterinarian or the director and the
institutional animal care and use committee.
Student intern program upon acceptance of application.
Quarterly publication of The Newsletter, devoted to
reports on chimpanzees.
Index Terms
Chimpanzee behavior, chimpanzee colony management,
chimpanzee newsletter, environmental enrichment.
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New Iberia Research Center
4401 West Admiral Doyle Drive
New Iberia, LA 70560
URL: www.louisiana.edu/Research/NIRC
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Principal
Investigator and Contact
Thomas J. Rowell, D.V.M.
337-482-0225; Fax: 337-373-0057
E-mail:
tjr7173@louisiana.edu
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To maintain and provide available research facilities
accredited by the Association for Assessment and
Accreditation of Laboratory Animal Care (AAALAC)
International, a ready source of great apes (chimpanzees)
of mixed ages and sex for use in biomedical and behavioral
sciences, and professional staff necessary to support
investigators in their research needs.
Vaccine development and testing; pharmacokinetic,
pharmacodynamic, preclinical safety, and efficacy studies.
The University of Louisiana at Lafayette-New Iberia
Research Center (UL Lafayette-NIRC) is an
AAALAC-International accredited nonhuman primate research
facility dedicated to the support of basic and applied
biomedical and behavioral research. All proposed programs
must be approved by the presenting institution and the UL
Lafayette-NIRC animal care and use committees.
State-of-the-art biomedical support facilities are
available that include access to ultrasound, radiography
with automatic processor and computer imagery for
diagnostic enhancement, and endoscopy and laparoscopy with
video monitors, camera and color photo imagery.
Diagnostic Laboratory
A 12,000-square-foot laboratory is available for
investigators' research support requirements. Capabilities
within the laboratory include, but are not limited to,
hematology, chemistry, microbiology, urinalysis,
parasitology, and histology. Among the investigator support
procedures we can provide are ficoll gradient isolation of
peripheral blood mononuclear cells, platelet aggregation
profiles, nonhuman primate lymphocyte proliferation assay,
and flow cytometry (lymphocyte enumeration). Emergency
generator power is accessible in each laboratory unit and
for all major instrumentation and critical freezers.
Animals
The center cares for approximately 360 chimpanzees and
5,500 New and Old World species of nonhuman primates. In
addition to chimpanzees, the following species of nonhuman
primates are being bred at the center: Vervet monkey
(Chlorocebus aethiops), cynomolgus macaque
(Macaca fascicularis), pigtailed macaque (M.
nemestrina), rhesus macaque (M. mulatta).
Index Terms
Animal husbandry, chimpanzee enrichment, chimpanzee health
care, chimpanzee reproduction, chimpanzee research,
infectious diseases, nonhuman primates, vaccine
development.
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M. D. Anderson Cancer Center
Department of Veterinary Sciences
650 Cool Water Drive
Bastrop, TX 78602
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Principal
Investigator and Contact
Michale E. Keeling, D.V.M.
512-321-3991; Fax: 512-332-5208
E-mail: mkeeling@mdanderson.org
Additional Contact
William C. Satterfield, D.V.M.
512-321-3991
E-mail: wsatterf@mdanderson.org
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To provide physically and behaviorally healthy chimpanzees
for critical biomedical research and testing; to conduct
relevant research projects of benefit to chimpanzee health,
productivity, and well-being; to develop procedures for
artificial insemination and embryo collection and transfer.
Develop and improve techniques of captive management;
investigate behavioral factors influencing improvements in
the husbandry and well-being of chimpanzees; support
collaborative programs in genetic management.
A demographically balanced group of approximately 100 physically
and behaviorally healthy chimpanzees to meet current and future
research and testing needs in the United States. The colony
is housed in eight 4,500-square-feet outdoor corrals in
multiple-male family groups. Complete facilities and
services are available for visiting scientists. Chimpanzees
are available to investigators supported by NIH grants and
contracts.
Biological Materials
Tissues and body fluids are available when coordinated with
preventive health care procedures.
Index Terms
Chimpanzee behavior, chimpanzee genetics, chimpanzee health
care, chimpanzee research, chimpanzee training and
enrichment.
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Emory University
954 North Gatewood Road, N.E.
Atlanta, GA 30322
URL: www.emory.edu/WHSC/YERKES
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Principal
Investigator and Contact
Kenneth G. Gould, Ph.D.
404-727-7714; Fax: 770-931-7502
E-mail: gould@rmy.emory.edu
Additional Contact
Thomas P. Gordon
404-727-7707; Fax: 404-727-0623
E-mail: gordon@rmy.emory.edu
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To maintain and study a population of chimpanzees (Pan
troglodytes) in cooperation with similar NIH-funded
projects and ensure availability of physically and
behaviorally normal chimpanzees for research and testing.
Several investigator-initiated NIH-funded projects are
ongoing. NCRR provides partial support for an environmental
enrichment program, training, and genetic characterization of the
colony.
The Yerkes Center encourages outside investigators to
consider chimpanzees for innovative research projects. Such
projects must be reviewed by the Yerkes Research Advisory
Committee and approved by the center director as well as
the Emory Institutional Animal Care and Use Committee.
Specimens
Tissues and body fluids may be obtained at the time of
routine health examinations in this research colony of 75
chimpanzees (Pan troglodytes). Cost estimates for
collecting, packaging, and shipping are available on
request.
Animals
Limited numbers of animals in excess of the needs of the
project may be available for research; priority is given to
NIH-sponsored projects.
Index Terms
Behavioral training, chimpanzee behavior, chimpanzee
research, environmental enrichment.
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Georgia State University
Viral Immunology Center
Department of Biology
50 Decatur Street
Atlanta, GA 30302-4118
URL: www.gsu.edu/bvirus
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Principal
Investigator and Contact
Julia K. Hilliard, Ph.D.
404-651-0808; Fax: 404-651-0821
Emergency: 404-358-8168
E-mail: biojkh@panther.gsu.edu
Additional Contacts
Richard Henkel, Ph.D.
404-651-0813; Fax: 404-651-0821
E-mail: biordh@panther.gsu.edu
Nete Priest
404-651-0808; Fax: 404-651-0814
E-mail: bioyyp@panther.gsu.edu
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To identify B-virus infections in humans and macaques and
study basic pathogenesis mechanisms of this and other
neurotropic herpesviruses; to develop control and
prevention strategies for B-virus infections in both humans
and macaques. All samples evaluated by the resource can be
used in ongoing research studies.
Assessment of evolutionary conservation among
alpha-herpesviruses by biochemical, immunological, and
molecular biological approaches; development of recombinant
reagents; identification of effective antiviral strategies
and design of putative vaccines; elucidation of host-virus
interactions during pathogenesis; collaborative
identification/exploration of putative alpha-herpesviruses
not previously described.
Diagnostic Services
This laboratory resource is designed to provide rapid
virological and serological analyses to identify
Herpesvirus simiae (B virus) infections in humans
and nonhuman primates, particularly macaques. Virological
analyses are performed by virus isolation, polypeptide
analysis, DNA restriction endonuclease analyses, and
experimental polymerase chain reaction (PCR). Serological
analyses include enzyme-linked immunosorbent assay (ELISA),
competition ELISA, and Western blot
analyses. The laboratory also provides telephone and mail
information to requestors seeking assistance for
identifying infections, and/or CDC-derived information for
handling human or macaque cases of B-virus infection. Staff
are available for collaboration in investigating cases of
B-virus infection in humans and nonhuman primates. Resource
staff perform all diagnostic services adjacent to the
herpesvirus research laboratory of the principal
investigator. This proximity permits consultation with and
additional assistance from staff members when required.
Other Services
Specialized biocontainment laboratory (BCL-4) facilities,
investigation of new animal models of herpesvirus disease,
antiviral testing, epidemiological analyses of
alpha-herpesvirus outbreaks, necropsy and autopsy
assistance for virological analyses of B-virus infections,
assistance in developing SPF primate colonies, and
isolation/characterization of nonhuman primate
alpha-herpesvirus.
Fees
Cost reimbursement for procedures performed to identify
potential B-virus infections in humans and nonhuman
primates is requested to maintain the resource.
Index Terms
Herpes B virus, pigtailed macaque, primates, retroviruses,
SPF primates.
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One Pine Hill Drive
Southborough, MA 01772
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Principal
Investigator and Contact
Keith G. Mansfield, D.V.M.
508-624-8183; Fax: 508-624-8190
E-mail: keith-mansfield@hms.harvard.edu
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Available animals in this SPF program are assigned to
approved AIDS research projects; priority is given to
Public Health Service-sponsored projects. This SPF breeding
program consists of 300 Indian-origin rhesus monkeys free
of Herpesvirus simiae, simian immunodeficiency
virus, simian T-lymphotropic virus 1, and type D
retrovirus. Animals are maintained in a closed colony.
Frequent antibody screening is performed to assure SPF
status.
Scientists wishing to conduct research at the center must
have projects reviewed and approved by the center director,
the executive committee, and the institutional animal care
and use committee. A brochure explaining the collaborative
research program is available from the center office. The
center's services are available to collaborating
scientists. Services include veterinary clinical services,
BL3 biocontainment facility, necropsies, clinical pathology
and hematology, electron microscopy, and isolation of viral
and bacterial agents.
Animals
SPF rhesus monkeys and blood samples are sold, as
available, to qualified outside investigators, subject to
the approval of the center director. A limited number of
common marmosets may be available.
Index Terms
AIDS, models, rhesus macaque, services, SIV.
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California National Primate Research Center
University of California, Davis
One Shields Avenue
Davis, CA 95616-8542
URL: www.crprc.ucdavis.edu
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Principal
Investigator and Contact
Jeffrey A. Roberts, D.V.M.
530-752-3670; Fax: 530-752-2880
E-mail: jaroberts@usdavis.edu
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The objective of this program is to produce pedigreed
rhesus macaques of Indian origin that are free of selected
viral pathogens. These agents include: Cercopithecine
herpesvirus 1 (herpes B), simian immunodeficiency virus
(SIV), simian T-lymphotropic virus 1, type D retrovirus,
and simian foamy virus (SFV). These animals are of known
pedigrees confirmed by microsatellite testing and are also
typed for Mamu A*01 alleles by the UC Davis Veterinary
Genetics Laboratory. Colony status is confirmed by frequent
viral screening through the Simian Retroviral Core
Laboratory.
Research programs are in place to use assisted reproductive
technology strategies to expand numbers of MamuA*01
positive animals and other genotypes that may be of
specific research interest. The center is also identifying
additional viral pathogens to be excluded from the SPF
population. Genetic studies are under way to determine
whether A*01 positive individuals are heterozygous or
homozygous.
Animals
Scientists wishing to use pedigreed Indian origin rhesus
macaques should contact the principal investigator.
Scientists wishing to conduct research at the California
National Primate Research Center should contact the
director. Information for research access to the primate
center is available at the CRPRC web site.
Other Services
Pedigree analysis and MHC typing for rhesus macaque is
available through the UC Davis Veterinary Genetics
Laboratory.
Index Terms
AIDS, assisted reproductive technology, genetics, rhesus
macaque, SPF primates.
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Oregon National Primate Research Center
Oregon Health Sciences University
Division of Pathobiology and Immunology
505 NW 185th Avenue
Beaverton, OR 97006-3499
URL: www.ohsu.edu/orprc
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Principal
Investigator and Contact
Michael K. Axthelm, D.V.M., Ph.D.
503-690-5236; Fax: 503-690-5524
E-mail: axthelmm@ohsu.edu
Contact
M. Susan Smith, Ph.D.
503-690-5300; Fax: 503-690-5569
E-mail: smithsu@ohsu.edu
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Enhance the Oregon National Primate Research Center's
(ORPRC) specific-pathogen-free (SPF) Indian-origin rhesus
macaque breeding resource by increasing the number of
pedigreed, genetically diverse females in the breeding
colony. Manage the resource for the production of
MHC-defined offspring of known parentage for use in
AIDS-related research through the use of breeder males that
are homozygous for major histocompatibility complex (MHC)
alleles that are important for assessing cell-mediated
immune function in vaccine development.
The SPF Indian-origin rhesus macaque breeding program at
the ORPRC consists of 425 female breeders. The total
population of 1,270 breeding age adults and juveniles are
free of simian immunodeficiency virus, T-lymphotrophic
virus 1, type D simian retroviruses and Herpesvirus
simiae. Frequent microbiologic monitoring is performed
to assure SPF status. Research objectives are focused on
doubling the number of pedigreed, genetically diverse
female breeders and production of offspring with defined
MHC class 1 haplotypes. Polymorphic microsatellite analyses
are being used to verify parentage, select appropriate
males and monitor genetic diversity in the breeding colony.
Selective breeding of MHC-typed animals and assisted
reproductive technology are being used to enhance
production of offspring with desired MHC haplotypes. The
SPF definition is being expanded in a portion of the colony
to include additional viral agents that are useful as
models of opportunistic infections in AIDS research or as
vectors for vaccine development.
Animals
Specific-pathogen-free juvenile Indian-origin rhesus
macaques, primarily males, for sale to NIH grantees and
other qualifying investigators for AIDS-related research.
Blood samples and other tissues and body fluids obtainable
using routine, noninvasive clinical procedures are
available to qualifying investigators with appropriate
institutional approvals for research animal use. Cost
estimates for collection, packaging and shipping are
available upon request. Allocation of animals produced
under this cooperative agreement will be determined by a
coordinating committee in consultation with the National
Center for Research Resources program administrator to
assure equitable distribution.
Services
The center's resources are available to collaborative NIH
grantees with appropriate animal care and use approval and
institutional contractual agreements. Resources include
veterinary clinical services, biological safety level-3
laboratory and animal containment facilities, anatomic
pathology, clinical pathology, microbiology, and flow
cytometry. Further information on the collaboration
research program is available from the Associate Director's
Office. Contact P. Michael Conn, Ph.D., 503-690-5297,
E-mail: connm@ohsu.edu
Index Terms
AIDS-related research resource, genetically defined rhesus
macaque, major histocompatibility complex, specific
pathogen-free.
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