RAPID ACCESS TO PREVENTIVE INTERVENTION DEVELOPMENT (RAPID) PROGRAM

Projects and Investigators

Projects Initiated in FY 2004
Projects Initiated in FY 2003
Projects Initiated in FY 2002
Projects Initiated in FY 2001
Projects Initiated in FY 2000

Projects Initiated in FY 2004

Principal Investigator & Institute	Title of Project	Prevention Agent Under Study
Dr. Michael B. Sporn Dartmouth Medical School	Bulk synthesis of a new triterpenoid, ethyl 2-carboxy-3,12-dioxooleana-1,9(11)-dien-28-oate (NSC #D722320, TP-222)	Synthetic Triterpenoid
Dr. Russell F. Jacoby University of Wisconsin-Madison	Polyamine analog SL11217 for prevention of colon and duodenal neoplasia	Porphyrin Polyamine Conjugate

Projects Initiated in FY 2003

Principal Investigator & Institute	Title of Project	Prevention Agent Under Study
Dr. Michael B. Sporn Dartmouth Medical School	Bulk Synthesis of the New Triterpenoid, 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) for Making New Derivatives with Improved Pharmacokinetics (concluded)	Synthetic Triterpenoids
Drs. Kimberly Kline and Bob G. Sanders University of Texas at Austin	Development of a-TEA, a Novel Tocopherol Based Anticancer Agent, for Prevention of Breast Cancer Recurrence and Metastasis	Synthetic Vitamin E Derivative
Dr. Paul Talalay Johns Hopkins University School of Medicine	Development of the Glucosinolate of Sulforaphane (Glucoraphanin) to Prevent Familial Adenomatous Polyposis, a Precursor of Colon Cancer, and to Eradicate Helicobacter pylori Infections, a Risk Factor for Gastric Cancer	Sulforaphane Derivative (Glucoraphanin)
Dr. Ling Jong SRI International	SR13668: A Novel Dietary Indole Analog for Cancer Prevention	Synthetic Indole-3-carbinol Derivative
Dr. Denis E. Corpet	Chemoprevention of Colorectal Tumors by Dietary Polyethylene Glycol (PEG)	Dietary Polyethylene Glycol (PEG)
Dr. Insu P. Lee Kanazawa University, Japan	Scale Up Production of a Potent Chemopreventive Agent, 1SY16 for Preclinical and Clinical Studies	Mushroom Extract (1SY16)

Projects Initiated in FY 2002

Principal Investigator & Institute	Title of Project	Prevention Agent Under Study
Dr. Thomas M. Badger University of Arkansas for Medical Sciences	Shiitake Mushrooms: Do They Prevent Cancer	Mycochemicals in Shiitake Mushrooms (Lentinus edodes)
Dr. Elaine L. Jacobson University of Arizona	Development of a Topical Niacin Prodrug for Skin Cancer Prevention	Topical Niacin Prodrug
Dr. Andrew J. Gescher University of Leicester, UK	Development of the Brown Rice Constituent Tricin as a Cancer Chemopreventive Agent	Flavonoid Tricin
Dr. Robert C. Rose University of Rochester School of Medicine	Preclinical and Clinical Investigation of the Safety and Tolerability of a Human Papillomavirus (HPV) Virus-Like Particle (VLP) Vaccine Co-administered in Combination with E. Coli Heat-labile Enterotoxin Mutant R192G (LT_R192G) by Oral, Intranasal, or Transcutaneous Routes of Immunization	Human Papillomavirus Virus-like Particle Vaccine
Dr. Donald D. Muccio University of Alabama	Preclinical Development of 9-cis-UAB30 for Breast Cancer Chemoprevention	9-cis-UAB30 (nuclear retinoid X receptor - RXR)
Dr. Leela Srinivas Adichunchanagiri Biotechnology and Cancer Research Institute, India	Beta-Turmerin, an Antioxidant from Turmeric (Curcuma longa)	Antioxidant from Turmeric (Curcuma longa)

Projects Initiated in FY 2001

Principal Investigator & Institute	Title of Project	Prevention Agent Under Study
Dr. Thomas W. Kensler Johns Hopkins University, Bloomberg School of Hygiene and Public Health	Development of a Novel, Non-calcemic, Hybrid Deltanoid QW-1624F₂-2	Synthetic vitamin D analog
Dr. Robert L. Garcea University of Colorado School of Medicine	Development of a Next Generation Human Papillomavirus Vaccine	Human Papillomavirus Vaccine
Dr. John M. Pezzuto Presently, Purdue University University of Illinois at Chicago	Preclinical Development of Four Flavonoids from Broussonetia Papyrifera	Flavonoids
Dr. Fung-Lung Chung Presently, Lombardi Comprehensive Cancer Center Georgetown University Medical Center American Health Foundation	Preclinical Development of Sulforaphane, a Major Constituent in Broccoli	Isothiocyanate; Sulforaphane
Dr. Michael B. Sporn Dartmouth Medical School	Bulk Synthesis of the New Triterpenoids, 2-Carboxy-DDO Methyl Ester and its Homolog, 2-Carboxy-DDO Ethyl Ester (concluded)	Triterpenoids

Projects Initiated in FY 2000

Principal Investigator & Institute	Title of Project	Prevention Agent Under Study
Peter Collin Coastside Research	Preclinical development of certain marine derived products, which are proprietary in nature	Marine-Derived Products
Dr. Clement Ip Roswell Park Cancer Institute	Evaluation of Se-methylselenocysteine for cancer prevention	Selenium Containing Amino Acid
Dr. Arthur G. Schwartz Temple University of School of Medicine, Fels Institute for Cancer Research and Molecular Biology	Development of DHEA-analog, Fluasterone, for efficacy trials in cancer prevention	Fluasterone
Dr. Thomas W. Kensler Johns Hopkins University, Bloomberg School of Hygiene and Public Health	Preclinical development of a new generation dithiolethione	5,6-dihydro-4H-cyclopenta-1,2 dithiole-3-thione
Dr. John M. Pezzuto Presently Purdue University University of Illinois at Chicago	Evaluation of 4'-Bromoflavone for cancer prevention	4'-Bromoflavone
Dr. Harold L. Newmark Rutgers, The State of University of New Jersey	Evaluation of farnesol and geraniol in human pancreatic cancer (concluded)	Farnesol and Geraniol
Dr. Eytan R. Barnea The Society of the Investigation of Early Pregnancy	Preclinical development of developmental peptides (DPs) as biopreventive agents (concluded)	Developmental Peptides

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